Small Maf (musculoaponeurotic fibrosarcoma) proteins are basic region leucine zipper-type transcription factors that can bind to DNA and regulate gene regulation.[1][2] There are three small Maf (sMaf) proteins, namely MafF, MafG, and MafK, in vertebrates.[3] HUGO Gene Nomenclature Committee (HGNC)-approved gene names of MAFF, MAFG and MAFK are “v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F, G, and K”, respectively.
Through the leucine zipper structures, sMafs form homodimers by themselves[2] and heterodimers with other specific bZIP transcription factors, such as transcription factors of the CNC (cap 'n' collar)[4][5][6][7] and Bach families.[8] Because CNC and Bach proteins cannot bind to DNA by themselves, sMafs are indispensable partners of the CNC and Bach families of transcription factors. Through interactions with these transcription factors, sMafs actively participate in transcriptional activation or repression depending on the nature of the heterodimeric partners.
^Fujiwara, KT (1993). "Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domain". Oncogene. 8 (9): 2371–80. PMID 8361754.
^ abKataoka, K (1995). "Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor". Mol. Cell. Biol. 15 (4): 2180–90. doi:10.1128/mcb.15.4.2180. PMC 230446. PMID 7891713.
^"NCBI Gene".
^Igarashi, K (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins". Nature. 367 (6463): 568–72. Bibcode:1994Natur.367..568I. doi:10.1038/367568a0. PMID 8107826. S2CID 4339431.
^Johnsen, O (1998). "Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. Nucleic Acids Res". Nucleic Acids Res. 26 (2): 512–20. doi:10.1093/nar/26.2.512. PMC 147270. PMID 9421508.
^Itoh, K (1997). "An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements". Biochem. Biophys. Res. Commun. 236 (2): 313–22. doi:10.1006/bbrc.1997.6943. PMID 9240432.
^Kobayashi, A (1999). "Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3". J. Biol. Chem. 274 (10): 6443–52. doi:10.1074/jbc.274.10.6443. PMID 10037736.
^Oyake, T (1996). "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site". Mol. Cell. Biol. 16 (11): 6083–95. doi:10.1128/mcb.16.11.6083. PMC 231611. PMID 8887638.
Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene. MafK is one of the smallMaf proteins, which...
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Neh1 domain is a CNC-bZIP domain that allows Nrf2 to heterodimerize with smallMaf proteins (MAFF, MAFG, MAFK). The Neh2 domain allows for binding of NRF2...
bZIP Maf is a domain found in Maf transcription factor proteins. It contains a leucine zipper (bZIP) domain, which mediates the transcription factor's...
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Johnsen O, Skammelsrud N, Luna L, Nishizawa M, Prydz H, Kolstø AB (1996). "SmallMaf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1"...
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"Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with smallMaf proteins". Nature. 367 (6463): 568–72. Bibcode:1994Natur.367..568I. doi:10...
gasoline-powered motor vehicle whereby the mass airflow meter, or MAF, is removed. The MAF is a component in a vehicle's intake system through which air flows...
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in using aluminum-silicon alloys more frequently for the engine block in small-displacement engines. Engine blocks of comparable design, but using Al-Si...
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The UK Food Guide. Retrieved 4 January 2013. "Kiwifruit vine disease by MAF Biosecurity NZ". Archived from the original on 12 March 2017. Retrieved 18...
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opposite orientation to this gene but does not seem to encode a protein. SmallMaf GRCh38: Ensembl release 89: ENSG00000156273 – Ensembl, May 2017 GRCm38:...
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