Dexamyl (or Drinamyl in the UK) was a brand name combination drug composed of sodium amobarbital (previously called amylbarbitone and its brand name Amytal) and dextroamphetamine sulfate (Dexedrine) within the same pill. It was widely abused, and is no longer manufactured.[1]
First introduced in 1950 by Smith, Kline & French (SKF), Dexamyl was marketed as an anorectic obesity medication as well as an anxiolytic and antidepressant medication that did not cause agitation. Racemic amphetamine sulfate had already been marketed over-the-counter (OTC) since 1933 as a nasal decongestant inhaler device under the brand name Benzedrine, and also as an oral tablet since 1938. Dexamyl utilized its enantiopure isomer of greater central nervous system (CNS) selectivity, dextroamphetamine sulfate, to elevate mood and suppress appetite, whereas the concomitant barbiturate was included to broadly counteract potential adverse effects from dextroamphetamine. Its name is a portmanteau of dextro- amphetamine and amyl- barbitone.
Dexamyl was discontinued in 1982 by SKF in favor of monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs) which were recently developed and shared treatment indications with Dexamyl yet lacked the high dependence potential and abuse liability which characterized long-term Dexamyl usage.
^The Primrose To Drug, Charleston Sunday Gazette-Mail, March 28, 1965, p. 54.
Dexamyl (or Drinamyl in the UK) was a brand name combination drug composed of sodium amobarbital (previously called amylbarbitone and its brand name Amytal)...
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