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Adipogenesis information


Histology features of a lipoblast, also known as an adipocyte precursor cell or preadipocyte.

Adipogenesis is the formation of adipocytes (fat cells) from stem cells.[1] It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing to the adipocyte precursor cells, also known as lipoblasts or preadipocytes which lose the potential to differentiate to other types of cells such as chondrocytes, myocytes, and osteoblasts.[2] Terminal differentiation is that preadipocytes differentiate into mature adipocytes. Adipocytes can arise either from preadipocytes resident in adipose tissue, or from bone-marrow derived progenitor cells that migrate to adipose tissue.[3]

Differentiated Adipocyte stained with Oil Red O
  1. ^ "Adipogenesis". Merriam-Webster. Retrieved 3 January 2020.
  2. ^ Gregoire FM, Smas CM, Sul HS (July 1998). "Understanding adipocyte differentiation". Physiological Reviews. 78 (3): 783–809. doi:10.1152/physrev.1998.78.3.783. PMID 9674695. S2CID 1538359.
  3. ^ Hausman GJ, Hausman DB (2006). "Search for the preadipocyte progenitor cell". Journal of Clinical Investigation. 116 (12): 3103–3106. doi:10.1172/JCI30666. PMC 1679717. PMID 17143324.

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Adipogenesis

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adipogenesis by binding to the promoter sites of PPARG and preventing its transcription. Rising levels of PPARG are required to initiate adipogenesis;...

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The AAMDC gene encodes an AMDC or Adipogenesis Associated Mth938 Domain Containing protein that is integral to various cellular processes. The protein...

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Adipocyte

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derived from mesenchymal stem cells which give rise to adipocytes through adipogenesis. In cell culture, adipocyte progenitors can also form osteoblasts, myocytes...

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intracellular triglycerides are well-known markers of osteoclastogenesis and adipogenesis. The increase in ALP is due to the substances within the fruits of Ligustrum...

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clear cytoplasm and a dark staining (hyperchromatic), indented nucleus. Adipogenesis Adipose differentiation-related protein Lipoblastoma List of human cell...

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WDTC1

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accumulation, and adipogenesis. WDTC1 is a factor in a complex composed of DDB1, CUL4, and ROC1 that restricts transcription in adipogenesis. Studies of phenotype...

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embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis. Erythroid Krüppel-like Factor (EKLF or KLF1) was the first Krüppel-like...

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weeks-treatment with ruxolitinib blunted senescent cell-mediated inhibition of adipogenesis and increased insulin sensitivity in 22-month-old mice. As of September...

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components play a significant role in the control of lipid metabolism and adipogenesis, which means dandelion can potentially be used to treat obesity. Dandelion...

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MicroRNA

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adipocytes. Studies to determine what role pluripotent stem cells play in adipogenesis, were examined in the immortalized human bone marrow-derived stromal...

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observing the chromatin landscapes of beige adipocytes have found that adipogenesis of these cells results from the formation of cell specific chromatin...

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are various hypotheses about its pathophysiology, including altered adipogenesis, microangiopathy, and damage to the lymphatic system disturbing its microcirculation...

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(November 2003). "Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated...

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of inflammation. Studies have disagreed about the effects of FFAR2 on adipogenesis (i.e., formation of fat cells and fat tissue from precursor cells) as...

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Bart Deplancke

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discovered the previously unknown adipogenesis-regulatory cells (Aregs), which are endowed with the ability to suppress adipogenesis, a finding that may have important...

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Thiazolidinedione

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histological improvements in steatosis severity. Thiazolindinediones induce adipogenesis in subcutaneous fat deposits by activating PPARγ receptors. This effect...

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Hyperandrogenism

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Additionally, obesity elevates inflammatory adipokines which leads to not only adipogenesis, but also heightened insulin resistance. Cushing's syndrome develops...

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regrowing hair cells after damage. SHH is important for regulating dermal adipogenesis by hair follicle transit-amplifying cells (HF-TACs). Specifically, SHH...

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Bone morphogenetic protein

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(GDFs). BMPs are also involved in adipogenesis and functional regulation of adipose tissue. BMP4 favors white adipogenesis, whereas BMP7 activates brown fat...

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Interleukin 11 (IL-11 or adipogenesis inhibitory factor) is a protein that in humans is encoded by the IL11 gene. IL-11 is a cytokine that was first isolated...

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Sodium pyruvate

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KH, Cho H, Han IO (2015-11-19). "Exogenous Sodium Pyruvate Stimulates Adipogenesis of 3T3-L1 Cells". Journal of Cellular Biochemistry. 117 (1): 39–48. doi:10...

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