positive regulation of skeletal muscle cell proliferation
pattern specification process
myotube differentiation
mesenchymal cell proliferation
male genitalia development
bud outgrowth involved in lung branching
limb bud formation
T cell differentiation in thymus
embryonic pattern specification
positive regulation of skeletal muscle tissue development
positive regulation of immature T cell proliferation in thymus
positive regulation of kidney smooth muscle cell differentiation
negative regulation of Wnt signaling pathway
anatomical structure formation involved in morphogenesis
ectoderm development
hindgut morphogenesis
spinal cord dorsal/ventral patterning
formation of anatomical boundary
oligodendrocyte differentiation
trachea development
prostate gland development
negative regulation of transcription elongation from RNA polymerase II promoter
limb development
vasculogenesis
primary prostatic bud elongation
heart looping
telencephalon regionalization
odontogenesis of dentin-containing tooth
positive regulation of mesenchymal cell proliferation
angiogenesis
positive regulation of epithelial cell proliferation involved in prostate gland development
positive regulation of striated muscle cell differentiation
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
embryonic digestive tract morphogenesis
apoptotic signaling pathway
inner ear development
hair follicle morphogenesis
cell population proliferation
metanephros development
lung epithelium development
negative regulation of canonical Wnt signaling pathway
regulation of proteolysis
branching involved in salivary gland morphogenesis
negative regulation of mesenchymal cell apoptotic process
positive regulation of neuroblast proliferation
dopaminergic neuron differentiation
intermediate filament organization
renal system development
cell fate commitment
regulation of transcription, DNA-templated
positive regulation of smoothened signaling pathway
androgen metabolic process
kidney development
lung development
negative regulation of protein catabolic process
thymus development
embryonic organ development
negative regulation of cell differentiation
negative regulation of dopaminergic neuron differentiation
embryonic digit morphogenesis
negative regulation of alpha-beta T cell differentiation
positive regulation of sclerotome development
epithelial-mesenchymal cell signaling
negative regulation of gene expression
lymphoid progenitor cell differentiation
negative thymic T cell selection
positive regulation of transcription, DNA-templated
positive regulation of Wnt signaling pathway
ventral midline development
central nervous system development
heart development
branching involved in ureteric bud morphogenesis
negative regulation of T cell proliferation
embryonic limb morphogenesis
positive regulation of cell differentiation
branching involved in prostate gland morphogenesis
positive regulation of mesenchymal cell proliferation involved in ureter development
establishment of cell polarity
branching involved in blood vessel morphogenesis
positive regulation of cerebellar granule cell precursor proliferation
neuroblast proliferation
pancreas development
positive regulation of protein import into nucleus
smoothened signaling pathway
oligodendrocyte development
camera-type eye development
spinal cord motor neuron differentiation
positive regulation of alpha-beta T cell differentiation
digestive tract morphogenesis
hair follicle development
positive regulation of oligodendrocyte differentiation
roof of mouth development
left lung development
striated muscle tissue development
positive regulation of T cell differentiation in thymus
cellular response to lithium ion
embryonic foregut morphogenesis
anatomical structure development
thalamus development
stem cell development
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
cell fate specification
negative regulation of apoptotic process
negative regulation of transcription by RNA polymerase II
regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
proteolysis
embryonic skeletal system development
regulation of protein localization to nucleus
odontogenesis
respiratory tube development
regulation of prostatic bud formation
thyroid gland development
negative regulation of cell migration
developmental growth
right lung development
determination of left/right asymmetry in lateral mesoderm
positive thymic T cell selection
mesenchymal smoothened signaling pathway involved in prostate gland development
canonical Wnt signaling pathway
regulation of gene expression
osteoblast development
negative regulation of cholesterol efflux
dorsal/ventral neural tube patterning
regulation of epithelial cell proliferation involved in prostate gland development
epithelial-mesenchymal signaling involved in prostate gland development
dorsal/ventral pattern formation
branching morphogenesis of an epithelial tube
lung lobe morphogenesis
embryonic forelimb morphogenesis
midbrain development
skin development
regulation of odontogenesis
regulation of mesenchymal cell proliferation involved in prostate gland development
mesenchymal cell proliferation involved in lung development
positive regulation of hh target transcription factor activity
prostate epithelial cord elongation
metanephric mesenchymal cell proliferation involved in metanephros development
endocytosis
lung morphogenesis
cell development
trachea morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
cell-cell signaling
salivary gland cavitation
hindbrain development
blood coagulation
negative regulation of kidney smooth muscle cell differentiation
somite development
cerebellar granule cell precursor proliferation
axon guidance
negative regulation of ureter smooth muscle cell differentiation
positive regulation of ureter smooth muscle cell differentiation
multicellular organism development
animal organ formation
intein-mediated protein splicing
determination of left/right symmetry
vasculature development
positive regulation of gene expression
regulation of cell population proliferation
embryonic morphogenesis
neural crest cell migration
polarity specification of anterior/posterior axis
positive regulation of cell population proliferation
artery development
protein localization to nucleus
Bergmann glial cell differentiation
forebrain development
neuron fate commitment
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
striated muscle cell differentiation
myoblast differentiation
lung-associated mesenchyme development
epithelial tube branching involved in lung morphogenesis
positive regulation of cell division
positive regulation of transcription by RNA polymerase II
anterior/posterior pattern specification
embryonic hindlimb morphogenesis
forebrain regionalization
cell proliferation in external granule layer
tracheoesophageal septum formation
regulation of signaling receptor activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6469
20423
Ensembl
ENSG00000164690
ENSMUSG00000002633
UniProt
Q15465
Q62226
RefSeq (mRNA)
NM_000193 NM_001310462
NM_009170
RefSeq (protein)
NP_000184 NP_001297391
NP_033196
Location (UCSC)
Chr 7: 155.8 – 155.81 Mb
Chr 5: 28.66 – 28.67 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sonic hedgehog protein (SHH) is encoded for by the SHH gene.[5] The protein is named after the video game character Sonic the Hedgehog.
This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French flag model.[6] This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres,[7] as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted.[8]
Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abnormal activation of SHH signaling in adult tissues has been implicated in various types of cancers including breast, skin, brain, liver, gallbladder and many more.[9]
^ abcGRCh38: Ensembl release 89: ENSG00000164690 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000002633 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Marigo V, Roberts DJ, Lee SM, Tsukurov O, Levi T, Gastier JM, et al. (July 1995). "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog". Genomics. 28 (1): 44–51. doi:10.1006/geno.1995.1104. PMID 7590746.
^Jaeger J, Martinez-Arias A (March 2009). "Getting the measure of positional information". PLOS Biology. 7 (3): e81. doi:10.1371/journal.pbio.1000081. PMC 2661971. PMID 19338391.
^Nanni L, Ming JE, Bocian M, Steinhaus K, Bianchi DW, Die-Smulders C, et al. (December 1999). "The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly". Human Molecular Genetics. 8 (13): 2479–2488. doi:10.1093/hmg/8.13.2479. PMID 10556296.
^Blaess S, Szabó N, Haddad-Tóvolli R, Zhou X, Álvarez-Bolado G (2015-01-06). "Sonic hedgehog signaling in the development of the mouse hypothalamus". Frontiers in Neuroanatomy. 8: 156. doi:10.3389/fnana.2014.00156. PMC 4285088. PMID 25610374.
^Jeng KS, Chang CF, Lin SS (January 2020). "Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments". International Journal of Molecular Sciences. 21 (3): 758. doi:10.3390/ijms21030758. PMC 7037908. PMID 31979397.
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Sonichedgehogprotein (SHH) is encoded for by the SHH gene. The protein is named after the video game character Sonic the Hedgehog. This signaling molecule...
Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated...
Doctor Ivo "Eggman" Robotnik is the main antagonist of Sega's Sonic the Hedgehog franchise. Eggman was created and designed by Naoto Ohshima as part of...
markets Sonic Team, a developer of video games SONIC, a brand name of Sega, S.A. SONICSonic the Hedgehog, a Sega video game franchise Sonic the Hedgehog (character)...
this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonichedgehog (protein)...
transcription factors is influenced by the gradients of BMP2 and sonichedgehogprotein (SHH). These factors are essential for coordinating early patterns...
have the gene. Additionally, the sonichedgehogprotein has been shown to block activity of the retinoblastoma protein, thereby inducing cell cycle re-entry...
posterior mesenchyme was the ZPA, which is now known to express the proteinsonichedgehog (Shh). One hypothesis is that at high concentrations, this unknown...
three "Drosophila" hedgehog homologs have been found in vertebrates: sonichedgehog, desert hedgehog, and Indian hedgehog. Sonichedgehog (SHH) has various...
(born 1984), stage name of Sharna Liguz, Australian musical artist Sonichedgehogprotein and gene Shoshoni language, ISO 639-3 alpha-3 code Students Helping...
such glycoproteins have been characterized: SonicHedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). Among these, Shh is the most potent...
The SHH gene gives instructions to produce a protein known as the SonicHedgehogprotein, and this protein's function is to aid in certain required embryonic...
development by interrupting the sonichedgehog (Shh) pathway. In healthy development, the Shh gene codes for Shh proteins. These proteins have a high affinity for...
secreted signaling molecules. Sonichedgehog (Shh) is a key player in patterning the ventral axis, while bone morphogenic proteins (BMPs) and Wnt family members...
of abnormal activity by the protein SHH (sonichedgehog). (The name of this protein was inspired by the Sonic the Hedgehog video game character and is...
transcription factors is influenced by the gradients of BMP2 and sonichedgehogprotein (SHH). These factors are essential for coordinating early patterns...
DNA-binding transcription factors and are mediators of Sonichedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates...
originally isolated from human glioblastoma cells. The Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell...
This has particularly been noted in patients with a defect in the sonichedgehog gene pathway and the disease formerly named CATCH22 for "cardiac anomaly...
Mfopou JK, De Groote V, Xu X, Heimberg H, Bouwens L (May 2007). "Sonichedgehog and other soluble factors from differentiating embryoid bodies inhibit...
of sonichedgehogprotein. In vivo adult rodent neural stem cells: Increase in cell number; increased expression of Sonichedgehog (Shh) protein. Delta4...
palmitoylation of sonichedgehog. Mutations in HHAT produce a phenotype that is similar to loss of hedgehog function. Finally the HHAT protein shares a short...
example, notch signaling) or from the adjacent cardiac mesoderm (Sonichedgehogprotein inhibition by Fibroblast growth factor). The differential of pancreatic...
membrane as a 7-pass transmembrane protein. Stimulation of the patched 12-pass transmembrane receptor by the sonichedgehog ligand leads to translocation of...
was known to play a role in the sonichedgehog pathway. When HHAT contains a loss-of-function mutation, less HHAT protein is produced. HHAT is necessary...
The sonichedgehog dentition expression is first found as a bilateral symmetrical pattern and is found in certain areas of the embryonic jaw. Sonic hedgehog...
Global Information
