positive regulation of transcription from RNA polymerase II promoter in response to stress
positive regulation of nitric oxide biosynthetic process
negative regulation of interleukin-6 production
cellular response to tumor necrosis factor
cellular response to organic cyclic compound
response to laminar fluid shear stress
in utero embryonic development
transcription, DNA-templated
positive regulation of transcription, DNA-templated
erythrocyte homeostasis
type I pneumocyte differentiation
cellular response to interleukin-1
cell morphogenesis
cellular response to cycloheximide
cellular response to hydrogen peroxide
erythrocyte maturation
positive regulation of transcription by RNA polymerase II
cellular response to fluid shear stress
negative regulation of transcription by RNA polymerase II
cellular stress response to acid chemical
negative regulation of sprouting angiogenesis
regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10365
16598
Ensembl
ENSG00000127528
ENSMUSG00000055148
UniProt
Q9Y5W3
Q60843
RefSeq (mRNA)
NM_016270 NM_006075 NM_016198
NM_008452
RefSeq (protein)
NP_057354
NP_032478
Location (UCSC)
Chr 19: 16.32 – 16.33 Mb
Chr 8: 73.07 – 73.08 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19.[5][6] It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000127528 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000055148 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kozyrev SV, Hansen LL, Poltaraus AB, Domninsky DA, Kisselev LL (Jun 1999). "Structure of the human CpG-island-containing lung Krüppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus". FEBS Lett. 448 (1): 149–52. doi:10.1016/S0014-5793(99)00348-8. PMID 10217429. S2CID 20878426.
Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19....
q arm of chromosome 3 in 10-20% of cases. Mutations in genes such as: 1 KLF2 (21% of cases), a transcription factor that indirectly regulates the NF-κB...
Additional genes, however, including certain members of the Klf family (Klf1, Klf2, Klf4, and Klf5), the Myc family (c-myc, L-myc, and N-myc), Nanog, and LIN28...
Hirschsprung's disease: Gene locus map 19p13.3 GTPBP3: GTP binding protein 3 19p13.11 KLF2: Krüppel-like factor 2, also known as Lung Krüppel-like factor. Gene map...
fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to...
channel TRPV4, subsequently facilitating the Notch signaling pathway via KLF2 and activating various downstream effectors such as BMP-2 and HER2/neu. In...
complex with STAU1, UPF1, and KLF2 mRNA, which promotes SMD and KLF2 transcripts. Knockdown of STAU1 or overexpression of KLF2 in SGC7901 and BGC823 increased...
[GBP5], dual-specificity phosphatase 3 [DUSP3], and Krüppel-like factor 2 [KLF2] genes to differentiate between active TB and other diseases. In 2007, a...
cells into the cortical plate. WWP1 has been shown to interact with: CPSF6, KLF2, and Reticulon 4 GRCh38: Ensembl release 89: ENSG00000123124 – Ensembl, May...
and is strongly affected by other pluripotency factors such as Nanog and KLF2. HTATSF1 has been shown to interact with SUPT5H and GTF2F2. GRCh38: Ensembl...
with value of 4 indicating the highest conservation and -0.5 the lowest. KLF2 and KLF5 had scores of 3.73 each. The species being compared were elephant...
expressions. It was found that Kruppel-like family of transcription factors (KLF2, KLF12, and KLF15), which were anti-inflammatory regulators, were down-regulated...
expression is inhibited by microRNA-92a and activated by transcription factor KLF2. In addition to LPA receptor-mediated signaling, PPAP2B is also associated...
in B lymphocytes is complex but it appears to operate in a network with KLF2 and KLF4 to influence the switch between spleen marginal zone and follicular...