Forkhead box protein O1 information

FOXO1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CO6, 3CO7, 3COA, 4LG0
Identifiers
Aliases	FOXO1, FKH1, FKHR, FOXO1A, forkhead box O1
External IDs	OMIM: 136533; MGI: 1890077; HomoloGene: 1527; GeneCards: FOXO1; OMA:FOXO1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	40,666,641 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	52,260,642 bp
RNA expression pattern
	Top expressed in
	decidua; ; synovial joint; ; synovial membrane; ; pericardium; ; middle frontal gyrus; ; left ovary; ; right ovary; ; tendon of biceps brachii; ; Achilles tendon; ; myometrium;
	Top expressed in
	secondary oocyte; ; molar; ; primary oocyte; ; zygote; ; dorsal striatum; ; aortic valve; ; ascending aorta; ; lymph node; ; Paneth cell; ; vestibular membrane of cochlear duct;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; beta-catenin binding; DNA-binding transcription factor activity; transcription factor binding; chromatin binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein phosphatase 2A binding; ubiquitin protein ligase binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coactivator binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; mitochondrion; nucleus;
Biological process	insulin receptor signaling pathway; negative regulation of fat cell differentiation; regulation of transcription, DNA-templated; positive regulation of protein catabolic process; glucose homeostasis; positive regulation of autophagy; cellular glucose homeostasis; cellular response to hyperoxia; regulation of transcription by RNA polymerase II; cellular response to starvation; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; regulation of reactive oxygen species metabolic process; transcription, DNA-templated; regulation of neural precursor cell proliferation; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; neuronal stem cell population maintenance; autophagy; positive regulation of transcription, DNA-templated; response to insulin; blood vessel development; cellular response to cold; response to fluoride; regulation of cell population proliferation; cellular response to insulin stimulus; positive regulation of apoptotic process; negative regulation of stress-activated MAPK cascade; cellular response to oxidative stress; enamel mineralization; cellular response to nitric oxide; positive regulation of gluconeogenesis; temperature homeostasis; negative regulation of transcription, DNA-templated; fat cell differentiation; negative regulation of canonical Wnt signaling pathway; endocrine pancreas development; protein acetylation; positive regulation of transcription by RNA polymerase II; cellular response to hydrogen peroxide; apoptotic process; anatomical structure morphogenesis; cell differentiation; negative regulation of cardiac muscle hypertrophy in response to stress; cytokine-mediated signaling pathway; energy homeostasis;
	Sources:Amigo / QuickGO
Orthologs
	2308
	56458
	ENSG00000150907
	ENSMUSG00000044167
	Q12778
	Q9R1E0
	NM_002015
	NM_019739
	NP_002006
	NP_062713
	Wikidata
View/Edit Human	View/Edit Mouse

Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene.^[5] FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis.^[6] It is primarily regulated through phosphorylation on multiple residues; its transcriptional activity is dependent on its phosphorylation state.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000150907 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044167 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ, Emanuel BS, Rovera G, Barr FG (November 1993). "Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma". Nature Genetics. 5 (3): 230–5. doi:10.1038/ng1193-230. PMID 8275086. S2CID 12374322.
^ Nakae J, Kitamura T, Kitamura Y, Biggs WH, Arden KC, Accili D (January 2003). "The forkhead transcription factor Foxo1 regulates adipocyte differentiation". Developmental Cell. 4 (1): 119–29. doi:10.1016/S1534-5807(02)00401-X. PMID 12530968.
^ Rena G, Guo S, Cichy SC, Unterman TG, Cohen P (June 1999). "Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B". The Journal of Biological Chemistry. 274 (24): 17179–83. doi:10.1074/jbc.274.24.17179. PMID 10358075.
^ Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T (June 1999). "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence". The Journal of Biological Chemistry. 274 (24): 17184–92. doi:10.1074/jbc.274.24.17184. PMID 10358076.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000150907 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044167 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8275086-5] Galili N, Davis RJ, Fredericks WJ, Mukhopadhyay S, Rauscher FJ, Emanuel BS, Rovera G, Barr FG (November 1993). "Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma". Nature Genetics. 5 (3): 230–5. doi:10.1038/ng1193-230. PMID 8275086. S2CID 12374322.

[pmid12530968-6] Nakae J, Kitamura T, Kitamura Y, Biggs WH, Arden KC, Accili D (January 2003). "The forkhead transcription factor Foxo1 regulates adipocyte differentiation". Developmental Cell. 4 (1): 119–29. doi:10.1016/S1534-5807(02)00401-X. PMID 12530968.

[pmid10358075-7] Rena G, Guo S, Cichy SC, Unterman TG, Cohen P (June 1999). "Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B". The Journal of Biological Chemistry. 274 (24): 17179–83. doi:10.1074/jbc.274.24.17179. PMID 10358075.

[8] Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T (June 1999). "Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence". The Journal of Biological Chemistry. 274 (24): 17184–92. doi:10.1074/jbc.274.24.17184. PMID 10358076.

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