Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Nverify (what is YN ?)
Infobox references
Chemical compound
Sodium pyruvate is a salt of the conjugate anion form of pyruvic acid, known as pyruvate. It is commonly added to cell culture media as an additional source of energy, but may also have protective effects against hydrogen peroxide. This was reported by Giandomenico et al.[1] and has been confirmed by several independent groups.
Due to pyruvate being an intermediate in many pathways for metabolism including glycolysis, sodium pyruvate has been used in many experiments involving cell cultures to provide more energy. In adipocytes it was found that sodium pyruvate promoted increased uptake of insulin-mediated glucose.[2] In the body, one way in which sodium pyruvate provides energy to cells is through pyruvate conversion to acetyl-CoA which then can enter the TCA cycle which produces energy and is linked to other energy producing processes.[2]
Along with having antioxidant properties and energy producing effects, sodium pyruvate has the ability to cross the blood-brain barrier and is used in several studies on brain injury because of these characteristics.[3][4]
^Giandomenico AR, Cerniglia GE, Biaglow JE, Stevens CW, Koch CJ (1997). "The importance of sodium pyruvate in assessing damage produced by hydrogen peroxide". Free Radic Biol Med. 23 (3): 426–34. doi:10.1016/S0891-5849(97)00113-5. PMID 9214579.
^ abPandit B, Sarkar A, Sinha B (2016). "Solution thermodynamics of sodium pyruvate in aqueous glycine solutions at T 298.15-313.15 K". Journal of the Serbian Chemical Society. 81 (11): 1283–1294. doi:10.2298/jsc151031034p. ISSN 0352-5139.
^Hwang JS, Kim SY, Jung EH, Kwon MY, Kim KH, Cho H, Han IO (2015-11-19). "Exogenous Sodium Pyruvate Stimulates Adipogenesis of 3T3-L1 Cells". Journal of Cellular Biochemistry. 117 (1): 39–48. doi:10.1002/jcb.25244. ISSN 0730-2312. PMID 26053972. S2CID 5100370.
^Fukushima M, Lee SM, Moro N, Hovda DA, Sutton RL (July 2009). "Metabolic and Histologic Effects of Sodium Pyruvate Treatment in the Rat after Cortical Contusion Injury". Journal of Neurotrauma. 26 (7): 1095–1110. doi:10.1089/neu.2008.0771. ISSN 0897-7151. PMC 2848946. PMID 19594384.
Sodiumpyruvate is a salt of the conjugate anion form of pyruvic acid, known as pyruvate. It is commonly added to cell culture media as an additional source...
alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base, CH3COCOO−, is an intermediate in several metabolic...
the effects of sodiumpyruvate (SP) and ethyl pyruvate (EP) as treatments to brain injury. This experiment concluded that the pyruvate treatments proved...
Pyruvate kinase deficiency is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red blood cells. Both autosomal...
Methyl pyruvate is the organic compound with the formula CH3C(O)CO2CH3. This colorless liquid is the methyl ester of pyruvic acid. It has attracted interest...
decarboxylase is a carboxy-lyase involved in the conversion of oxaloacetate into pyruvate. It is categorized under EC 4.1.1.3. Oxaloacetate decarboxylase activity...
medium incorporates egg yolk, phosphate buffer, magnesium salts, and sodiumpyruvate; amino acids may be added, but glycerol is not included, as it is inhibitory...
DCA have been studied as potential drugs because they inhibit the enzyme pyruvate dehydrogenase kinase. Although preliminary studies found that DCA can slow...
respiratory pathogen Haemophilus influenzae. Pyruvate is converted into acetyl-coenzyme A (acetyl-CoA) by the enzyme pyruvate dehydrogenase. This acetyl-CoA is then...
anion intermediate. In 2005, Scheidt and coworkers reported the use of sodiumpyruvate, which loses CO2 to form the Breslow intermediate. Similarly, in 2011...
peptone, horse serum, glucose and sodiumpyruvate provide nutrients for the growth of Streptococcus agalactiae, sodiumpyruvate provide also protective effect...
containing peptone, casamino acids, yeast extract, glucose, soluble starch, sodiumpyruvate and inorganic salts. Although T. roseus is found in soil and sediment...
role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes...
to pyruvate by an aminotransferase enzyme, regenerating the α-ketoglutarate, and converting the pyruvate to alanine. The net result is that pyruvate and...
decarboxylation reactions from the citric acid cycle include: pyruvate to acetyl-CoA (see pyruvate decarboxylation) oxalosuccinate to α-ketoglutarate α-ketoglutarate...
is high, glucose is broken down and oxidized to pyruvate, and lactate is then produced from the pyruvate faster than the body can process it, causing lactate...
broken down into pyruvate in ten enzymatic steps. A significant proportion of pyruvate is converted into lactate (the blood lactate-to-pyruvate ratio is normally...
Global Information
verify (what is 
?)
