YWHAZ information

YWHAZ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IB1, 1QJA, 1QJB, 2C1J, 2C1N, 2O02, 2WH0, 3CU8, 3NKX, 3RDH, 4BG6, 4FJ3, 4HKC, 4IHL, 4N7G, 4N7Y, 4N84, 4WRQ, 4ZDR, 1A38, 1A4O, 1A37, 5D2D, 5D3F, 5EXA, 5EWZ
Identifiers
Aliases	YWHAZ, 14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD, HEL-S-93, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, POPCHAS
External IDs	OMIM: 601288 MGI: 109484 HomoloGene: 56528 GeneCards: YWHAZ
Gene location (Human)
Chr.	Chromosome 8 (human)
End	100,953,388 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	36,797,173 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; amniotic fluid; ; human penis; ; prefrontal cortex; ; oral cavity; ; hair follicle; ; Brodmann area 23; ; islet of Langerhans; ; superior frontal gyrus; ; Brodmann area 9;
	Top expressed in
	olfactory tubercle; ; subiculum; ; nucleus accumbens; ; medial dorsal nucleus; ; piriform cortex; ; lateral geniculate nucleus; ; habenula; ; medial geniculate nucleus; ; prefrontal cortex; ; mammillary body;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; transcription factor binding; protein binding; identical protein binding; protein kinase binding; ubiquitin protein ligase binding; RNA binding; cadherin binding; transmembrane transporter binding;
Cellular component	cytoplasm; cytosol; blood microparticle; focal adhesion; melanosome; nucleoplasm; mitochondrion; extracellular exosome; cytoplasmic vesicle membrane; extracellular space; nucleus; vesicle; glutamatergic synapse; hippocampal mossy fiber to CA3 synapse;
Biological process	regulation of mRNA stability; negative regulation of apoptotic process; establishment of Golgi localization; Golgi reassembly; platelet activation; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; membrane organization; signal transduction; protein targeting; regulation of cell death; cytokine-mediated signaling pathway; regulation of synapse maturation; synaptic target recognition;
	Sources:Amigo / QuickGO
Orthologs
	7534
	22631
	ENSG00000164924
	ENSMUSG00000022285
	P63104
	P63101
NM_001135699; NM_001135700; NM_001135701; NM_001135702; NM_003406;
	NM_145690
	NM_001253805; NM_001253806; NM_001253807; NM_011740; NM_001356569
NP_001129171; NP_001129172; NP_001129173; NP_001129174; NP_003397;
	NP_663723
	NP_001240734; NP_001240735; NP_001240736; NP_035870; NP_001343498
	Wikidata
View/Edit Human	View/Edit Mouse

14-3-3 protein zeta/delta (14-3-3ζ) is a protein that in humans is encoded by the YWHAZ gene on chromosome 8.^[5]^[6] The protein encoded by this gene is a member of the 14-3-3 protein family and a central hub protein for many signal transduction pathways.^[6]^[7] 14-3-3ζ is a major regulator of apoptotic pathways critical to cell survival and plays a key role in a number of cancers and neurodegenerative diseases.^[7]^[8]^[9]^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164924 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022285 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tommerup N, Leffers H (April 1996). "Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization". Genomics. 33 (1): 149–50. doi:10.1006/geno.1996.0176. PMID 8617504.
^ ^a ^b "Entrez Gene: YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide".
^ ^a ^b Nishimura Y, Komatsu S, Ichikawa D, Nagata H, Hirajima S, Takeshita H, et al. (April 2013). "Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma". British Journal of Cancer. 108 (6): 1324–31. doi:10.1038/bjc.2013.65. PMC 3619260. PMID 23422756.
^ Weerasekara VK, Panek DJ, Broadbent DG, Mortenson JB, Mathis AD, Logan GN, et al. (December 2014). "Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9". Molecular and Cellular Biology. 34 (24): 4379–88. doi:10.1128/MCB.00740-14. PMC 4248729. PMID 25266655.
^ Liang R, Chen XQ, Bai QX, Wang Z, Zhang T, Yang L, et al. (2014). "Increased 14-3-3ζ expression in the multidrug-resistant leukemia cell line HL-60/VCR as compared to the parental line mediates cell growth and apoptosis in part through modification of gene expression". Acta Haematologica. 132 (2): 177–86. doi:10.1159/000357377. PMID 24603438. S2CID 13410244.
^ Matta A, Siu KW, Ralhan R (May 2012). "14-3-3 zeta as novel molecular target for cancer therapy". Expert Opinion on Therapeutic Targets. 16 (5): 515–23. doi:10.1517/14728222.2012.668185. PMID 22512284. S2CID 38941816.
^ Joo Y, Schumacher B, Landrieu I, Bartel M, Smet-Nocca C, Jang A, et al. (October 2015). "Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau" (PDF). FASEB Journal. 29 (10): 4133–44. doi:10.1096/fj.14-265009. PMID 26103986. S2CID 32696302.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164924 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022285 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8617504-5] Tommerup N, Leffers H (April 1996). "Assignment of the human genes encoding 14,3-3 Eta (YWHAH) to 22q12, 14-3-3 zeta (YWHAZ) to 2p25.1-p25.2, and 14-3-3 beta (YWHAB) to 20q13.1 by in situ hybridization". Genomics. 33 (1): 149–50. doi:10.1006/geno.1996.0176. PMID 8617504.

[entrez-6] "Entrez Gene: YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide".

[pmid23422756-7] Nishimura Y, Komatsu S, Ichikawa D, Nagata H, Hirajima S, Takeshita H, et al. (April 2013). "Overexpression of YWHAZ relates to tumor cell proliferation and malignant outcome of gastric carcinoma". British Journal of Cancer. 108 (6): 1324–31. doi:10.1038/bjc.2013.65. PMC 3619260. PMID 23422756.

[pmid25266655-8] Weerasekara VK, Panek DJ, Broadbent DG, Mortenson JB, Mathis AD, Logan GN, et al. (December 2014). "Metabolic-stress-induced rearrangement of the 14-3-3ζ interactome promotes autophagy via a ULK1- and AMPK-regulated 14-3-3ζ interaction with phosphorylated Atg9". Molecular and Cellular Biology. 34 (24): 4379–88. doi:10.1128/MCB.00740-14. PMC 4248729. PMID 25266655.

[pmid24603438-9] Liang R, Chen XQ, Bai QX, Wang Z, Zhang T, Yang L, et al. (2014). "Increased 14-3-3ζ expression in the multidrug-resistant leukemia cell line HL-60/VCR as compared to the parental line mediates cell growth and apoptosis in part through modification of gene expression". Acta Haematologica. 132 (2): 177–86. doi:10.1159/000357377. PMID 24603438. S2CID 13410244.

[pmid22512284-10] Matta A, Siu KW, Ralhan R (May 2012). "14-3-3 zeta as novel molecular target for cancer therapy". Expert Opinion on Therapeutic Targets. 16 (5): 515–23. doi:10.1517/14728222.2012.668185. PMID 22512284. S2CID 38941816.

[pmid26103986-11] Joo Y, Schumacher B, Landrieu I, Bartel M, Smet-Nocca C, Jang A, et al. (October 2015). "Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau" (PDF). FASEB Journal. 29 (10): 4133–44. doi:10.1096/fj.14-265009. PMID 26103986. S2CID 32696302.

YWHAZ information

and 22 Related for: YWHAZ information

YWHAZ

Vimentin

Tau protein

P53

Housekeeping gene

KIAA0232

ZNF839

TSC2

AKT1

LIMK1

GP1BA

TNFAIP3

GP1BB

YWHAB

Protein kinase C zeta type

WWC2

FAM13B

LAPTM4B

HMGN1

CDC25B

YWHAH

PRKCE