Protein kinase C, zeta (PKCζ), also known as PRKCZ, is a protein in humans that is encoded by the PRKCZ gene. The PRKCZ gene encodes at least two alternative transcripts, the full-length PKCζ and an N-terminal truncated form PKMζ. PKMζ is thought to be responsible for maintaining long-term memories in the brain. The importance of PKCζ in the creation and maintenance of long-term potentiation was first described by Todd Sacktor and his colleagues at the SUNY Downstate Medical Center in 1993.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000067606 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029053 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Sacktor TC, Osten P, Valsamis H, Jiang X, Naik MU, Sublette E (1993). "Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation". Proceedings of the National Academy of Sciences of the United States of America. 90 (18): 8342–8346. Bibcode:1993PNAS...90.8342S. doi:10.1073/pnas.90.18.8342. PMC 47352. PMID 8378304.
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