PRKCE information

PRKCE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WH0
Identifiers
Aliases	PRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon
External IDs	OMIM: 176975; MGI: 97599; HomoloGene: 48343; GeneCards: PRKCE; OMA:PRKCE - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,187,990 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	86,965,347 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; sural nerve; ; lateral nuclear group of thalamus; ; parietal lobe; ; postcentral gyrus; ; right lung; ; middle temporal gyrus; ; sperm; ; superior frontal gyrus; ; entorhinal cortex;
	Top expressed in
	anterior amygdaloid area; ; subiculum; ; lateral septal nucleus; ; olfactory tubercle; ; dentate gyrus; ; prefrontal cortex; ; hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; ventromedial nucleus; ; medial dorsal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein kinase C activity; actin monomer binding; 14-3-3 protein binding; signal transducer activity; metal ion binding; signaling receptor activator activity; protein serine/threonine kinase activity; kinase activity; protein binding; calcium-independent protein kinase C activity; enzyme binding; ethanol binding; enzyme activator activity; ATP binding;
Cellular component	cytoplasm; cell periphery; cytosol; Golgi apparatus; membrane; plasma membrane; endoplasmic reticulum; mitochondrion; perinuclear region of cytoplasm; cytoskeleton; nucleus;
Biological process	positive regulation of cell-substrate adhesion; release of sequestered calcium ion into cytosol; regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of cellular glucuronidation; intracellular signal transduction; positive regulation of actin filament polymerization; cellular response to ethanol; Fc-gamma receptor signaling pathway involved in phagocytosis; phosphorylation; immune system process; regulation of release of sequestered calcium ion into cytosol; negative regulation of sodium ion transmembrane transporter activity; positive regulation of lipid catabolic process; positive regulation of wound healing; positive regulation of epithelial cell migration; positive regulation of synaptic transmission, GABAergic; TRAM-dependent toll-like receptor 4 signaling pathway; locomotory exploration behavior; platelet activation; positive regulation of cytokinesis; cell division; negative regulation of protein ubiquitination; protein phosphorylation; macrophage activation involved in immune response; response to morphine; positive regulation of signaling receptor activity; regulation of lipid metabolic process; cell adhesion; cellular response to prostaglandin E stimulus; peptidyl-serine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; cell cycle; positive regulation of mucus secretion; positive regulation of fibroblast migration; cellular response to hypoxia; lipopolysaccharide-mediated signaling pathway; signal transduction; positive regulation of insulin secretion; positive regulation of MAPK cascade; regulation of peptidyl-tyrosine phosphorylation; apoptotic process; positive regulation of protein localization to plasma membrane; positive regulation of catalytic activity;
	Sources:Amigo / QuickGO
Orthologs
	5581
	18754
	ENSG00000171132
	ENSMUSG00000045038
	Q02156
	P16054
	NM_005400
	NM_011104
	NP_005391
	NP_035234
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene.^[5]^[6] PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. PKCε is clinically significant in that it is a central player in cardioprotection against ischemic injury and in the development of cardiac hypertrophy.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171132 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045038 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Basta P, Strickland MB, Holmes W, Loomis CR, Ballas LM, Burns DJ (Sep 1992). "Sequence and expression of human protein kinase C-epsilon". Biochimica et Biophysica Acta. 1132 (2): 154–60. doi:10.1016/0167-4781(92)90006-l. PMID 1382605.
^ Lehel C, Olah Z, Jakab G, Anderson WB (Feb 1995). "Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1406–10. doi:10.1073/pnas.92.5.1406. PMC 42528. PMID 7877991.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171132 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045038 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1382605-5] Basta P, Strickland MB, Holmes W, Loomis CR, Ballas LM, Burns DJ (Sep 1992). "Sequence and expression of human protein kinase C-epsilon". Biochimica et Biophysica Acta. 1132 (2): 154–60. doi:10.1016/0167-4781(92)90006-l. PMID 1382605.

[pmid7877991-6] Lehel C, Olah Z, Jakab G, Anderson WB (Feb 1995). "Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1406–10. doi:10.1073/pnas.92.5.1406. PMC 42528. PMID 7877991.

PRKCE information

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