positive regulation of signaling receptor activity
regulation of lipid metabolic process
cell adhesion
cellular response to prostaglandin E stimulus
peptidyl-serine phosphorylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
cell cycle
positive regulation of mucus secretion
positive regulation of fibroblast migration
cellular response to hypoxia
lipopolysaccharide-mediated signaling pathway
signal transduction
positive regulation of insulin secretion
positive regulation of MAPK cascade
regulation of peptidyl-tyrosine phosphorylation
apoptotic process
positive regulation of protein localization to plasma membrane
positive regulation of catalytic activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5581
18754
Ensembl
ENSG00000171132
ENSMUSG00000045038
UniProt
Q02156
P16054
RefSeq (mRNA)
NM_005400
NM_011104
RefSeq (protein)
NP_005391
NP_035234
Location (UCSC)
Chr 2: 45.65 – 46.19 Mb
Chr 17: 86.48 – 86.97 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene.[5][6] PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at mitochondria. PKCε is clinically significant in that it is a central player in cardioprotection against ischemic injury and in the development of cardiac hypertrophy.
^ abcGRCh38: Ensembl release 89: ENSG00000171132 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000045038 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Basta P, Strickland MB, Holmes W, Loomis CR, Ballas LM, Burns DJ (Sep 1992). "Sequence and expression of human protein kinase C-epsilon". Biochimica et Biophysica Acta. 1132 (2): 154–60. doi:10.1016/0167-4781(92)90006-l. PMID 1382605.
^Lehel C, Olah Z, Jakab G, Anderson WB (Feb 1995). "Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1406–10. doi:10.1073/pnas.92.5.1406. PMC 42528. PMID 7877991.
kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large PKC family of protein kinases that...
(PRKCG) novel - require DAG but not Ca2+ for activation PKC-δ (PRKCD) PKC-ε (PRKCE) PKC-η (PRKCH) PKC-θ (PRKCQ) atypical - require neither Ca2+ nor DAG for...
chromosome 12q12-q13. Keratin 1 has been shown to interact with desmoplakin and PRKCE. 34βE12 GRCh38: Ensembl release 89: ENSG00000167768 – Ensembl, May 2017...