anchored component of external side of plasma membrane
extracellular exosome
extracellular space
extracellular matrix
Biological process
blood coagulation, intrinsic pathway
hemostasis
fibrinolysis
negative regulation of protein kinase activity
cytokine-mediated signaling pathway
blood coagulation
platelet activation
cell surface receptor signaling pathway
cell adhesion
cell morphogenesis
regulation of blood coagulation
negative regulation of receptor signaling pathway via JAK-STAT
thrombin-activated receptor signaling pathway
platelet aggregation
regulation of megakaryocyte differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
2811
14723
Ensembl
ENSG00000185245
ENSMUSG00000050675
UniProt
P07359
O35930
RefSeq (mRNA)
NM_000173
NM_010326
RefSeq (protein)
NP_000164
NP_034456
Location (UCSC)
Chr 17: 4.93 – 4.94 Mb
Chr 11: 70.53 – 70.53 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene.
^ abcGRCh38: Ensembl release 89: ENSG00000185245 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000050675 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene. Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein...
platelet to bind to vWF, which is exposed upon damage to vasculature. The vWF A1 domain (yellow) interacts with the extracellular domain of GP1ba (blue)....
platelet to bind to VWF, which is exposed upon damage to vasculature. The VWF A1 domain (yellow) interacts with the extracellular domain of GP1ba (blue)....
can be produced in immune thrombocytopenic purpura. Components include GP1BA and GP1BB. It complexes with Glycoprotein IX. Bode AP, Read MS, Reddick...
a vWF-independent manner. It binds specifically to platelet GPIbalpha (GP1BA) to a distinct binding site from that of flavocetin-A. It is isolated from...
the GP9 gene. CD42b Platelet glycoprotein Ib alpha chain encoded by the GP1BA gene. CD42c Platelet glycoprotein Ib beta chain encoded by the GP1BB gene...
neutrophils and deposited on vessel walls. Platelet glycoprotein Ib alpha (GP1BA;GPIbα) is the receptor for S100A8/A9 on platelets. In vitro, platelets adhere...
receptor is a heterodimer composed of 2 polypeptide chains, an alpha chain (GP1BA; MIM 606672) and a beta chain (GP1BB; MIM 138720), that are linked by disulfide...
dysplasia and atelosteogenesis type I. FLNB has been shown to interact with GP1BA, Filamin, FBLIM1, PSEN1, CD29 and PSEN2. Larsen syndrome GRCh38: Ensembl...