RAC(Rho family)-alpha serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases that contain SH2 (Src homology 2-like) protein domains.[5] It is commonly referred to as PKB, or by both names as "Akt/PKB".
^ abcGRCh38: Ensembl release 89: ENSG00000142208 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001729 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT1 gene. This enzyme belongs to the AKT subfamily of serine/threonine kinases...
to PKB alpha and Akt1 alone.[citation needed] Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce...
for the disorder, Lindhurst et al. identified an activating mutation in AKT1 kinase in a mosaic state. Previous research had suggested the condition linked...
set of transcription factors perturbed by AKT1 activation. These results incriminate somatic mutations of AKT1 as probable driver events in the pathogenesis...
2-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations, as detected by an FDA-approved test, following progression...
and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP...
GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking protein with a conserved...
resveratrol had been identified, including NQO2 (alone and in interaction with AKT1), GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. It was unclear at...
present in about one-fourth of meningiomas. Mutations in the TRAF7, KLF4, AKT1, and SMO genes are commonly expressed in benign skull-base meningiomas. Mutations...
COX-2, respectively. HoxA5 also upregulates the tumor suppressor p53 and Akt1 by downregulation of PTEN. Suppression of HoxA5 has been shown to attenuate...
L'histoire du soldat The Devil/Narrator Copenhagen Phil 2015 Danske Permafrost AKT1 Danmarks Lydteater Live in the Dome of Visions, Copenhagen The Evil Erik...
subfamily "PTHR24352:SF30" for AKT1. GO molecular function: This tell you what are the functions of your query gene; e.g. AKT1 has protein kinase activity...
dysregulation of the PI3K pathway via PI3KCA/PI3KCB mutations (6% of tumors) or AKT1 (2% of tumors). Prostate cancer is the second-most frequently diagnosed cancer...
spontaneous apoptosis (AKT1), severe diabetes (AKT2), small brains (AKT3), and growth deficiency (AKT1/AKT2). Mice heterozygous for AKT1 have increased lifespan...
symbol for the gene v-akt murine thymoma viral oncogene homolog 1, which is AKT1, cannot be said to be an acronym for the name, and neither can any of its...
mutations in the PIK3CA gene and 2 had tumor cells with mutations in the AKT1 gene. The mutations occurred in these genes' hot spots, i.e. areas of a genes'...
Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene. GRCh38: Ensembl release 89: ENSG00000204673 – Ensembl,...
in ovarian cancer subtypes Gene mutated Mutation type Subtype Prevalence AKT1 amplification 3% AKT2 amplification/mutation 6%, 20% ARID1A point mutation...
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