Protein-coding gene in the species Homo sapiens
LAPTM4B Identifiers Aliases LAPTM4B , LAPTM4beta, LC27, lysosomal protein transmembrane 4 betaExternal IDs OMIM: 613296; MGI: 1890494; HomoloGene: 10182; GeneCards: LAPTM4B; OMA:LAPTM4B - orthologs Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1 Start 97,775,057 bp[1] End 97,853,013 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 34,238,174 bp[2] End 34,284,448 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium Epithelium of choroid plexus right ventricle myocardium cardiac muscle tissue of right atrium pancreatic ductal cell myocardium of left ventricle secondary oocyte beta cell biceps brachii
Top expressed in motor neuron ciliary body Epithelium of choroid plexus facial motor nucleus substantia nigra primary oocyte Paneth cell retinal pigment epithelium medullary collecting duct primitive streak
More reference expression data
BioGPS
Gene ontology Molecular function
protein binding
kinase binding
ubiquitin protein ligase binding
phosphatidylinositol bisphosphate binding
ceramide binding Cellular component
endomembrane system
integral component of membrane
membrane
early endosome
multivesicular body, internal vesicle
lysosome
lysosomal membrane
endosome
plasma membrane
endosome membrane
late endosome membrane
multivesicular body membrane
cell projection Biological process
endosome organization
endosome transport via multivesicular body sorting pathway
negative regulation of lysosomal protein catabolic process
negative regulation of transforming growth factor beta1 production
regulation of lysosomal membrane permeability
regulation of lysosome organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Location (UCSC) Chr 8: 97.78 – 97.85 Mb Chr 15: 34.24 – 34.28 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Lysosomal-associated transmembrane protein 4B is a protein that in humans is encoded by the LAPTM4B gene.[5]
LAPTM4B protein contains a lysosome localization motif and localizes on late endosomes and lysosomes.
^ a b c GRCh38: Ensembl release 89: ENSG00000104341 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022257 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Entrez Gene: LAPTM4B lysosomal associated protein transmembrane 4 beta". 
Global Information
