M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.[5]
CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000101224 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027330 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Galaktionov K, Beach D (February 1992). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins". Cell. 67 (6): 1181–94. doi:10.1016/0092-8674(91)90294-9. PMID 1836978. S2CID 9659637.
^"Entrez Gene: CDC25B cell division cycle 25 homolog B (S. pombe)".
Most other model organisms examined have three Cdc25s, designated Cdc25A, Cdc25B, and Cdc25C. An exception is the nematode Caenorhabditis elegans, which...
enzyme that in humans is encoded by the CDC25B gene. CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase...
and in vivo, been shown to reduce expression of the CDC25B gene, which codes for production of CDC25B enzyme. CDC stands for cell-division-cycle, and is...
shows an example of GNM calculation for the catalytic domain of the protein Cdc25B, a cell division cycle dual-specificity phosphatase. Diagonalization of...
Cyclin A2/CDK2 activity begins in early S phase and increases during G2. Cdc25B has been shown to dephosphorylate Tyr15 on CDK2 in early-to-mid G2 in a...
The third class of PTPs contains three cell cycle regulators, CDC25A, CDC25B and CDC25C, which dephosphorylate CDKs at their N-terminal, a reaction required...
there is a need for further research. MELK has been shown to interact with CDC25B. GRCh38: Ensembl release 89: ENSG00000165304 – Ensembl, May 2017 GRCm38:...
activates nuclear kinase Weel/MtyI. Weel/Mtyl inhibits cell division cycle 25B (CDC25B) which is a main activator for Cyclin-dependent kinase (CDK). This leads...
Cdc25 gene (found e.g. in the fungus species S. pombe), designated Cdc25A, Cdc25B, and Cdc25C. In contrast, some invertebrates harbour two (e.g., the Drosophila...
enzymes are Cdc25A which controls the checkpoints of G1/S and G2/M as well as Cdc25B and Cdc25C which both control the G2/M checkpoint. Myt 1 and Wee 1 kinases...
with Miller–Dieker syndrome. YWHAE has been shown to interact with: C-Raf, CDC25B, HDAC4, HERG, IRS1 and IGF1R, MAP3K3, NDEL1, NGFRAP1, and TGF beta 1. 14-3-3...
Ducommun B (2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase". Oncogene. 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. PMID 10713667...
PMC 528928. PMID 15489334. Mirey G, Chartrain I, Froment C, et al. (2006). "CDC25B phosphorylated by pEg3 localizes to the centrosome and the spindle poles...
include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress-related...
"Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase". FEBS Lett. 318 (3): 331–4. doi:10.1016/0014-5793(93)80540-B...
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