Vicriviroc information

Vicriviroc
Names
	IUPAC name 5-({4-[(3S)-4-{2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl}-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl}carbonyl)-4,6-dimethylpyrimidine
Identifiers
CAS Number	306296-47-9 ; 599179-03-0 (maleate) ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL82301 ;
ChemSpider	21106404 ;
IUPHAR/BPS	807;
MeSH	Vicriviroc
PubChem CID	3009355;
UNII	TL515DW4QS ; EP3QG127N9 (maleate) ;
CompTox Dashboard (EPA)	DTXSID40897719 ;
	InChI InChI=1S/C28H38F3N5O2/c1-19-16-35(14-15-36(19)24(17-38-5)22-6-8-23(9-7-22)28(29,30)31)27(4)10-12-34(13-11-27)26(37)25-20(2)32-18-33-21(25)3/h6-9,18-19,24H,10-17H2,1-5H3/t19-,24?/m0/s1 Key: CNPVJJQCETWNEU-XGLRFROISA-N ; InChI=1/C28H38F3N5O2/c1-19-16-35(14-15-36(19)24(17-38-5)22-6-8-23(9-7-22)28(29,30)31)27(4)10-12-34(13-11-27)26(37)25-20(2)32-18-33-21(25)3/h6-9,18-19,24H,10-17H2,1-5H3/t19-,24?/m0/s1 Key: CNPVJJQCETWNEU-XGLRFROIBK;
	SMILES FC(F)(F)c1ccc(cc1)[C@H](COC)N2CCN(C[C@@H]2C)C3(C)CCN(CC3)C(=O)c4c(C)ncnc4C;
Properties
Chemical formula	C28H38F3N5O2
Molar mass	533.629 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Vicriviroc, previously named SCH 417690 and SCH-D, is a pyrimidine CCR5 entry inhibitor of HIV-1. It was developed by the pharmaceutical company Schering-Plough. Merck decided to not pursue regulatory approval for use in treatment-experienced patients because the drug did not meet primary efficacy endpoints in late stage trials. Clinical trials continue in patients previously untreated for HIV.

Vicriviroc information

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Vicriviroc

CCR5 receptor antagonist

List of antiviral drugs

CCR5

CXCL10

CXCL9

Ubiquitin

Interleukin 8

CXCR4

Chemokine

Entry inhibitor

Platelet factor 4

Maraviroc

CXCR3

CCL2

CXCL2

Macrophage migration inhibitory factor

CCR4

CXC chemokine receptors

CCR2

CXCL1

CXCL13

CCL21

Ulocuplumab

Chemokine receptor