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Edrophonium information


Edrophonium
Clinical data
Trade namesTensilon
AHFS/Drugs.comFDA Professional Drug Information
ATC code
  • V04CX07 (WHO)
Identifiers
IUPAC name
  • N-Ethyl-3-hydroxy-N,N-dimethylbenzenaminium
CAS Number
  • 312-48-1 ☒N
PubChem CID
  • 8307
DrugBank
  • DB01010 checkY
ChemSpider
  • 8006 checkY
UNII
  • 70FP3JLY7N
KEGG
  • D00994 checkY
ChEBI
  • CHEBI:4759 checkY
ChEMBL
  • ChEMBL1128 checkY
CompTox Dashboard (EPA)
  • DTXSID4046943 Edit this at Wikidata
Chemical and physical data
FormulaC10H16NO+
Molar mass166.244 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • [Cl-].Oc1cccc(c1)[N+](C)(CC)C
InChI
  • InChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H checkY
  • Key:BXKDSDJJOVIHMX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Edrophonium is a readily reversible acetylcholinesterase inhibitor. It prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction. It is sold under the trade names Tensilon and Enlon (according to FDA Orange Book).

and 26 Related for: Edrophonium information

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Edrophonium

Last Update:

Edrophonium is a readily reversible acetylcholinesterase inhibitor. It prevents breakdown of the neurotransmitter acetylcholine and acts by competitively...

Word Count : 612

Tensilon test

Last Update:

A tensilon test, also called an edrophonium test, is a pharmacological test used for the diagnosis of certain neural diseases, especially myasthenia gravis...

Word Count : 446

Myasthenia gravis

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Diagnosis can be supported by blood tests for specific antibodies, the edrophonium test, electromyography (EMG), or a nerve conduction study. MG is generally...

Word Count : 5998

Cholinergic crisis

Last Update:

crisis can be distinguished from myasthenia gravis by the use of the drug edrophonium (Tensilon), as it only worsens the paralysis caused by cholinergic crisis...

Word Count : 616

Norgesic

Last Update:

ISBN 1-930513-59-3. "Determination That TENSILON and TENSILON Preservative Free (Edrophonium Chloride) Injectable and Other Drug Products Were Not Withdrawn From...

Word Count : 143

Acetylcholinesterase inhibitor

Last Update:

Piperidines Donepezil Tacrine, also known as tetrahydroaminoacridine (THA) Edrophonium Huperzine A Ladostigil Ungeremine Lactucopicrin Acotiamide Hybrid/bitopic...

Word Count : 2384

Parasympathomimetic drug

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sympathetic nervous system. Reversible cholinesterase inhibitors Donepezil Edrophonium Neostigmine Physostigmine Pyridostigmine Rivastigmine Tacrine Caffeine...

Word Count : 618

Pancuronium bromide

Last Update:

reversed by anticholinesterasics, such as neostigmine, pyridostigmine, and edrophonium. Workers at Organon were inspired by the structure of the aminosteroid...

Word Count : 959

Caffeine

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 19813

Tetraodontidae

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toxin is metabolized. Case reports suggest anticholinesterases such as edrophonium may be effective.[citation needed] Shimonoseki – Japanese city known...

Word Count : 3030

Naja

Last Update:

Yambao ML; Sangalang R; et al. (4 December 1986). "Positive response to edrophonium in patients with neurotoxic envenoming by cobras (Naja naja philippinensis)...

Word Count : 3812

Simpson test

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bilateral. It is sometimes done in conjunction with tensilon test, where edrophonium is injected to look for reversibility of eyelid drooping. In myaesthenia...

Word Count : 284

Choline

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 6134

Tetrahydrocannabinol

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 5328

Donepezil

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 2823

Sarin

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 4651

Botulism

Last Update:

examination, nerve conduction test (electromyography, or EMG), and an edrophonium chloride (Tensilon) test for myasthenia gravis. A definite diagnosis...

Word Count : 8587

Botulinum toxin

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 11724

Acetylcholine

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 4232

Ocular myasthenia

Last Update:

during the day (with increasing extraocular muscle fatigue). A tensilon (edrophonium chloride) test can be used, which temporarily blocks the breakdown of...

Word Count : 1452

ATC code V04

Last Update:

V04CX04 Mannitol V04CX05 13C-urea V04CX06 Hexaminolevulinate V04CX07 Edrophonium V04CX08 Carbon monoxide V04CX09 Patent blue V04CX10 Pafolacianine V04CX11...

Word Count : 295

Anticholinergic

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 2388

List of dangerous snakes

Last Update:

Yambao ML; Sangalang R; et al. (4 December 1986). "Positive response to edrophonium in patients with neurotoxic envenoming by cobras (Naja naja philippinensis)...

Word Count : 17216

Physostigmine

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 2351

Neostigmine

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 1380

Rivastigmine

Last Update:

Terestigmine; Others: Acotiamide Ambenonium Caffeine Donepezil EA-3990 EA-4056 Edrophonium Galantamine Huperzine A Huprine W Huprine X Huprine Y Ipidacrine Itopride...

Word Count : 1691
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