96%, albumin (about 75%) and alpha1-acid glycoprotein (21%).[6][5]
Metabolism
CYP2D6, CYP3A4, and glucuronidation.[5] Four major metabolites, two of which are active.[6][5]
Onset of action
Peak plasma levels in 3–4 h.[6][5]
Elimination half-life
70 hours[7] Around 100 hours in elderly patients.[5]
Duration of action
With daily dosing, steady-state concentration is reached in 15–21 days.[6][5]
Excretion
0.11–0.13 (L/h/kg); excreted mostly by the kidneys. Around 17% is excreted unchanged in the urine. About 15% to 20% is excreted in feces.[5][6] Steady-state clearance is similar at all ages.[5]
Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type.[3][4][8] It appears to result in a small benefit in mental function and ability to function.[9] Use, however, has not been shown to change the progression of the disease.[10] Treatment should be stopped if no benefit is seen.[11] It is taken by mouth or via a transdermal patch.[3][4][8]
Common side effects include nausea, trouble sleeping, aggression, diarrhea, feeling tired, and muscle cramps.[8][11] Serious side effects may include abnormal heart rhythms, urinary incontinence, and seizures.[8] Donepezil is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents.[8][5]
Donepezil was approved for medical use in the United States in 1996.[8] It is available as a generic medication.[11] In 2021, it was the 131st most commonly prescribed medication in the United States, with more than 4million prescriptions.[12][13]
^Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^"Donepezil Hydrochloride 10 mg Film-coated tablets". Electronic Medicines Compendium. Archived from the original on 8 September 2022. Retrieved 8 September 2022.
^ abc"Aricept- donepezil hydrochloride tablet, film coated Aricept ODT- donepezil hydrochloride tablet, orally disintegrating". DailyMed. 23 December 2021. Retrieved 15 March 2022.
^ abc"Adlarity- donepezil hydrochloride patch". DailyMed. 11 March 2022. Retrieved 19 June 2022.
^ abcdefghijCite error: The named reference Kum2020 was invoked but never defined (see the help page).
^ abcdefSeltzer B (October 2005). "Donepezil: a review". Expert Opinion on Drug Metabolism & Toxicology. 1 (3). Informa Healthcare: 527–536. doi:10.1517/17425255.1.3.527. PMID 16863459. S2CID 32689288. there is a linear relationship between dose and pharmacodynamic effects, measured as red blood cell acetylcholinesterase inhibition and clinical efficacy. Despite being 96% bound to plasma proteins, it has few interactions with other drugs, and the 5-mg dose can be given safely to patients with mild-to-moderate hepatic and renal-disease.
^Asiri YA, Mostafa GA (2010). "Donepezil". Profiles of Drug Substances, Excipients and Related Methodology. Vol. 35. Elsevier. pp. 117–50. doi:10.1016/s1871-5125(10)35003-5. ISBN 978-0-12-380884-4. ISSN 1871-5125. PMID 22469221. S2CID 206178636. Plasma donepezil concentrations decline with a half-life of approximately 70 h. Sex, race, and smoking history have no clinically significant influence on plasma concentrations of donepezil [46–51].
^ abcdef"Donepezil Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 4 February 2019.
^Birks JS, Harvey RJ (June 2018). "Donepezil for dementia due to Alzheimer's disease". The Cochrane Database of Systematic Reviews. 2018 (6): CD001190. doi:10.1002/14651858.CD001190.pub3. PMC 6513124. PMID 29923184.
^Swedish Council on Health Technology Assessment (June 2008). "Dementia – Caring, Ethics, Ethnical and Economical Aspects: A Systematic Review". SBU Systematic Reviews. PMID 28876770.
^ abcBritish national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 300. ISBN 978-0-85711-338-2.
^"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Donepezil - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
Donepezil, sold under the brand name Aricept among others, is a medication used to treat dementia of the Alzheimer's type. It appears to result in a small...
these are available commercially. The three available are rivastigmine, donepezil, and galantamine, while tacrine is not. They are generally used to treat...
not appear to be any benefit in mild disease. Memantine when added to donepezil in those with moderate-to-severe dementia resulted in "limited improvements"...
supports usage in schizophrenia patients. Its efficacy is similar to donepezil and tacrine. Doses below 6 mg/d may be ineffective. The effects of this...
is true for dopamine antagonists. In one case study, a patient taking donepezil reported an elevation in mood and energy levels which led to hypergraphia...
family Lamiaceae. Alpha-pinene – noncompetitive reversible Piperidines Donepezil Tacrine, also known as tetrahydroaminoacridine (THA) Edrophonium Huperzine...
CADASIL, but as of 2017 there are no clinical studies supporting its use. Donepezil, normally used for Alzheimer's Disease, was shown not to improve executive...
approved in the United States by the FDA to treat Alzheimer's include donepezil, rivastigmine, and galantamine. These drugs work to increase the levels...
pharmacologist, known for his discovery of Donepezil. Sugimoto's research on E2020 (now called Donepezil), an acetylcholinesterase inhibitor, first began...
antipsychotic primarily used to control antisocial hypersexual behaviour Aricept (donepezil) – used to slow the progression of Alzheimer's disease Ativan (lorazepam)...
is no known cure for dementia. Acetylcholinesterase inhibitors such as donepezil are often used and may be beneficial in mild to moderate disorder. The...
hallucinations respond well to the drug Donepezil, making it another potential treatment for the condition. Donepezil, which belongs to a class of medication...
acetylcholinesterase inhibitors, three of which are currently in use: donepezil, galantamine, and rivastigmine. Recently, it has begun to be used in the...
and 60 to 80 minutes respectively. Acetylcholinesterase inhibitor Donepezil: Donepezil is a widely used acetylcholinesterase inhibitor indicated for Alzheimer's...
improve cognitive function for individuals with mild cognitive impairment; donepezil showed only minor, short-term benefits and was associated with significant...
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