Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. TPH catalyzes the following chemical reaction
Tryptophanhydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the monoamine neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine...
Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophanhydroxylase together make up the family of aromatic amino acid hydroxylases (AAAHs). Tyrosine...
Tryptophanhydroxylase 1 (TPH1) is an isoenzyme of tryptophanhydroxylase which in humans is encoded by the TPH1 gene. TPH1 was first discovered to support...
Tryptophanhydroxylase 2 (TPH2) is an isozyme of tryptophanhydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic...
radical intermediate was proposed, analyses of the related tryptophan and tyrosine hydroxylases have suggested that the reaction instead proceeds through...
tryptophan functions as a biochemical precursor for the following compounds: Serotonin (a neurotransmitter), synthesized by tryptophanhydroxylase. Melatonin...
catalyst, mainly hydroxylases. Tetrahydrobiopterin is a cofactor for tryptophanhydroxylase (TPH) for the conversion of L-tryptophan (TRP) to 5-hydroxytryptophan...
para-chlorophenylalanine (PCPA), acts as a selective and irreversible inhibitor of tryptophanhydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin...
biosynthesis pathway is the hydroxylation of L-tryptophan's indole ring by the enzyme tryptophanhydroxylase, resulting in the formation of 5-hydroxytryptophan...
amino acid tryptophan. Tryptophan is synthesized into serotonin through the addition of a hydroxyl group by the enzyme tryptophanhydroxylase and the subsequent...
Xermelo) is a prodrug of telotristat, which is an inhibitor of tryptophanhydroxylase. It is formulated as telotristat etiprate — a hippurate salt of...
ligand-gated cation channel. Serotonin is synthesized from tryptophan by tryptophanhydroxylase, and then further by decarboxylase. A lack of 5-HT at postsynaptic...
synthesized from the amino acid L-tryptophan by a short metabolic pathway consisting of two enzymes, tryptophanhydroxylase (TPH) and aromatic amino acid...
and depression, as one of the few parts of the brain that creates tryptophanhydroxylase. The median raphe nucleus contains 5-hydroxytryptamine (serotonin...
phenylalanine, is due to a lack of the enzyme phenylalanine hydroxylase. A dietary lack of tryptophan can cause stunted skeletal development. Excessive intake...
suggested explanation for IED is a polymorphism of the gene for tryptophanhydroxylase, which produces a serotonin precursor; this genotype is found more...
This inhibits the synthesis of norepinephrine by inhibiting tyrosine hydroxylase. The S-enantiomer of methyldopa is a competitive inhibitor of the enzyme...
obtained medications, and some dietary supplements (e.g., St. John's wort or tryptophan). It is vital that a doctor supervise such combinations to avoid adverse...
V.; McGeer, P. L.; McGeer, E. G. (1968). "The Distribution of TryptophanHydroxylase in Cat Brain". Journal of Neurochemistry. 15 (12): 1431–5. doi:10...
decarboxylations being confined to the central nervous system: 5-HTP to serotonin Tryptophan to tryptamine Phenylalanine to phenethylamine L-tyrosine to tyramine Centrally...
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