oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
oxidoreductase activity
Cellular component
cytosol
neuron projection
Biological process
cellular response to lithium ion
response to glucocorticoid
response to activity
serotonin biosynthetic process
response to estrogen
response to calcium ion
aromatic amino acid family metabolic process
response to nutrient levels
circadian rhythm
indolalkylamine biosynthetic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
121278
216343
Ensembl
ENSG00000139287
ENSMUSG00000006764
UniProt
Q8IWU9
Q8CGV2
RefSeq (mRNA)
NM_173353
NM_173391
RefSeq (protein)
NP_775489
NP_775567
Location (UCSC)
Chr 12: 71.94 – 72.19 Mb
Chr 10: 114.91 – 115.02 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain. Until the discovery of TPH2 in 2003,[5] serotonin levels in the central nervous system were believed to be regulated by serotonin synthesis in peripheral tissues, in which tryptophan hydroxylase is the dominant form.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000139287 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000006764 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M (January 2003). "Synthesis of serotonin by a second tryptophan hydroxylase isoform". Science. 299 (5603): 76. doi:10.1126/science.1078197. PMID 12511643. S2CID 7095712.
^Zill P, Büttner A, Eisenmenger W, Möller HJ, Ackenheil M, Bondy B (2005). "Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study". Journal of Psychiatric Research. 41 (1–2): 168–173. doi:10.1016/j.jpsychires.2005.05.004. PMID 16023677.
Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic...
has been shown to exist in two forms: TPH1, found in several tissues, and TPH2, which is a neuron-specific isoform. Serotonin can be synthesized from tryptophan...
TPH gene until 2003. A second form was found in the mouse (Tph2), rat and human brain (TPH2) and the original TPH was then renamed to TPH1. Tryptophan...
genes associated with ADHD include SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2, and BDNF. A common variant of a gene called latrophilin 3 is estimated to...
chromosomes 11 and 12 and encode two different homologous enzymes TPH1 and TPH2 (sequence identity 71%). TPH1 is mostly expressed in tissues that express...
correction for multiple testing. On the other hand, two polymorphisms in TPH2 were identified as being associated with bipolar disorder. Due to the inconsistent...
J; Jia, M; Qiao, D; Qiu, H; Sokolove, J; Zhang, J; Pan, Z (March 2016). "TPH2 gene polymorphisms and bipolar disorder: A meta-analysis". American Journal...
genes associated with ADHD include SERT, HTR1B, SNAP25, GRIN2A, ADRA2A, TPH2, and BDNF. A common variant of a gene called latrophilin 3 is estimated to...
were also later seen alongside non-classic U-to-C alterations in brain cell TPH2 (tryptophan hydroxylase 2) transcripts. Although the reverse amination might...
Proudnikov, Scott Kellogg, Ann Ho, Jurg Ott & Mary Jeanne Kreek (March 2008). "TPH2 and TPH1: association of variants and interactions with heroin addiction"...
Global Information
