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Median raphe nucleus information


This image shows the location of the raphe nucleus (seen in the bottom of the image near the brain stem) while also providing information about how it is used in the serotonin pathway which has various cognitive functions. The Median Raphe Nucleus is a part of the Raphe Nucleus.
Median raphe nucleus
Details
Identifiers
Latinnucleus raphes medianus, nucleus centralis superior
NeuroNames562
NeuroLex IDbirnlex_889
TA98A14.1.05.603
TA25956
FMA72465
Anatomical terms of neuroanatomy
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The median raphe nucleus (MRN or MnR), also known as the nucleus raphes medianus (NRM)[1] or superior central nucleus, is a brain region composed of polygonal, fusiform, and piriform neurons, which exists rostral to the nucleus raphes pontis. The MRN is located between the posterior end of the superior cerebellar peduncles and the V. Afferents of the motor nucleus.[2] It is one of two nuclei, the other being the dorsal raphe nucleus (DnR), in the midbrain-pons.[3]

The MRN projects extensively to the hippocampus, which is known to be essential for the formation of long-term memory. One recent study found that this raphe–hippocampus pathway plays a critical role in regulation of hippocampal activity and likely associated memory consolidation processes. It has also been found to play a role in anxiety and depression, as one of the few parts of the brain that creates tryptophan hydroxylase.

  1. ^ Federative Committee on Anatomical Terminology (FCAT) (1998). Terminologia Anatomica. Stuttgart: Thieme
  2. ^ Walker, Emily P.; Tadi, Prasanna (2019), "Neuroanatomy, Nucleus Raphe", StatPearls, StatPearls Publishing, PMID 31335079, retrieved 2019-09-24
  3. ^ Beck, Sheryl G.; Pan, Yu-Zhen; Akanwa, Adaure C.; Kirby, Lynn G. (February 2004). "Median and dorsal raphe neurons are not electrophysiologically identical". Journal of Neurophysiology. 91 (2): 994–1005. doi:10.1152/jn.00744.2003. ISSN 0022-3077. PMC 2830647. PMID 14573555.

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