Methyldopa, sold under the brand name Aldomet among others, is a medication used for high blood pressure.[1] It is one of the preferred treatments for high blood pressure in pregnancy.[1] For other types of high blood pressure including very high blood pressure resulting in symptoms other medications are typically preferred.[1] It can be given by mouth or injection into a vein.[1] Onset of effects is around 5 hours and they last about a day.[1]
Common side effects include sleepiness.[1] More severe side effects include red blood cell breakdown, liver problems, and allergic reactions.[1] Methyldopa is in the alpha-2 adrenergic receptor agonist family of medication. It works by stimulating the brain to decrease the activity of the sympathetic nervous system.[1]
Methyldopa was discovered in 1960.[2] It is on the World Health Organization's List of Essential Medicines.[3]
^ abcdefghij"Methyldopa". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^Walker RS (2012). Trends and Changes in Drug Research and Development. Springer Science & Business Media. p. 109. ISBN 9789400926592. Archived from the original on 2016-09-14.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Methyldopa, sold under the brand name Aldomet among others, is a medication used for high blood pressure. It is one of the preferred treatments for high...
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galactorrhea includes eliciting a history for various medications or foods (methyldopa, opioids, antipsychotics, serotonin reuptake inhibitors) and for behavioral...
mepivacaine). Corbadrine is also a metabolite of the antihypertensive drug methyldopa, and plays a role in its pharmacology and effects. α-Methyldopamine α-Methyltyramine...
pressure medications such as clonidine, guanabenz, guanfacine (Tenex), or methyldopa; heart rhythm medications such as amiodarone (Cordarone, Pacerone), mexiletine...
swelling. Phentermine may decrease the effect of drugs like clonidine, methyldopa, and guanethidine. Drugs to treat hypothyroidism may increase the effect...
DDC inhibitors are benserazide (Ro-4-4602), difluoromethyldopa, and α-methyldopa. Carbidopa, an inhibitor of aromatic amino acid decarboxylation, is a...
abnormal steroid metabolism), mastitis and medications such as digitalis, methyldopa (an antihypertensive), spironolactone, certain diuretics, oxymetholone...
sympathetic tone from the vasomotor center. This acts to raise blood pressure. Methyldopa acts on the vasomotor center, leading to selective stimulation of α2-adrenergic...
nervous system. Examples include 5-MeO-αMT (mimicking serotonin) and α-methyldopa. These chemicals can be accumulated by a neuron or secretory cell, are...
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