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Triamterene information


Triamterene
Clinical data
Trade namesDyrenium, others
AHFS/Drugs.comMonograph
MedlinePlusa682337
Pregnancy
category
  • AU: C
Routes of
administration
By mouth
ATC code
  • C03DB02 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: WARNING[1]Rx-only
Pharmacokinetic data
Bioavailability30-70%
Protein binding67%
Metabolismhydroxylation to para-hydroxytriamterene
Elimination half-life1-2 hours, active metabolite 3 hours
Excretionrenal <50%, 21% unchanged
Identifiers
IUPAC name
  • 6-phenylpteridine-2,4,7-triamine
CAS Number
  • 396-01-0 checkY
PubChem CID
  • 5546
IUPHAR/BPS
  • 4329
DrugBank
  • DB00384 checkY
ChemSpider
  • 5345 checkY
UNII
  • WS821Z52LQ
KEGG
  • D00386 ☒N
ChEMBL
  • ChEMBL585 checkY
CompTox Dashboard (EPA)
  • DTXSID6021373 Edit this at Wikidata
ECHA InfoCard100.006.278 Edit this at Wikidata
Chemical and physical data
FormulaC12H11N7
Molar mass253.269 g·mol−1
InChI
  • InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19) checkY
  • Key:FNYLWPVRPXGIIP-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Triamterene (traded under names such as Dyrenium and Dytac) is a potassium-sparing diuretic often used in combination with thiazide diuretics for the treatment of high blood pressure or swelling. The combination with hydrochlorothiazide, is known as hydrochlorothiazide/triamterene.

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

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Triamterene

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Triamterene (traded under names such as Dyrenium and Dytac) is a potassium-sparing diuretic often used in combination with thiazide diuretics for the...

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Diuretic

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[citation needed] Epithelial sodium channel blockers: amiloride and triamterene.[citation needed] The term "calcium-sparing diuretic" is sometimes used...

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Hydrochlorothiazide

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HCT (with aliskiren) Potassium sparing diuretics – Dyazide and Maxzide triamterene Use of hydrochlorothiazide is prohibited by the World Anti-Doping Agency...

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Pseudoporphyria

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Antifungals - voriconazole Diuretics - furosemide, chlorthalidone, butamide, triamterene/hydrochlorothiazide Antiarrhythmics - amiodarone Chemotherapy - 5-fluorouracil...

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Mylan

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(50 mg hydrochlorothiazide and 75 mg triamterene, compared with Dyazide's 25 mg hydrochlorothiazide and 50 mg triamterene). This drug had to get approval as...

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Amiloride

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are already taking potassium-sparing drugs (e.g. spironolactone and triamterene) or who are taking potassium supplements (e.g. potassium chloride) in...

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Ketamine

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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Nephrotoxicity

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obstruction: sulphonamides, methotrexate, aciclovir, diethylene glycol, triamterene. Main article : Acute interstitial nephritis β-lactam antibiotics, vancomycin...

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List of GSK plc products

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tamsulosin hydrochloride) Duvroq (daprodustat) Dyazide (hydrochlorothiazide/triamterene) Eskazole (albendazole) Eumovate (clobetasone butyrate) Flixonase (fluticasone...

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Malononitrile

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(2007). Important outlets include the synthesis of thiamine, the drug triamterene and minoxidil, and the dyes disperse Yellow 90 and disperse Blue 354...

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Macrocytic anemia

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trimethoprim/sulfamethoxazole), antiretroviral medications, cholestyramine, triamterene, and nitrous oxide. Other disorders which cause macrocytosis without...

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Calcium channel blocker

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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Benzthiazide

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it was also sold in combination with the potassium-sparing diuretic triamterene under the trade name Dytide. The same combination is still available...

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Salt substitute

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following prescription drugs should not use a salt substitute: amiloride, triamterene, Dytac, captopril and other angiotensin-converting enzyme inhibitors...

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Amitriptyline

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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Barbiturate

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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Lorazepam

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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Ascites

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be sought. Spironolactone (or other distal-tubule diuretics, such as triamterene and amiloride) is the drug of choice, because it blocks the aldosterone...

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Cocaine

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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Buprenorphine

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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Hyperkalemia

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and tacrolimus. For potassium-sparing diuretics, such as amiloride and triamterene; both the drugs block epithelial sodium channels in the collecting tubules...

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Drug nomenclature

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co-codamol is codeine-paracetamol (acetaminophen), and co-triamterzide is triamterene-hydrochlorothiazide. The USP ceased maintaining PENs, but the similar...

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Epithelial sodium channel

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modulated by the mineralocorticoid aldosterone. It can be blocked by either triamterene or amiloride, which are used medically to serve as diuretics. In the...

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IARC group 2B

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dioxide Toluene diisocyanates Toxaphene (Polychlorinated camphenes) Triamterene Trichlormethine (Trimustine hydrochloride) Trichloroacetic acid 2,4,6-Trichlorophenol...

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Metamizole

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metamizole. Oral anticoagulants (blood thinners), lithium, captopril, triamterene and antihypertensives may also interact with metamizole, as other pyrazolones...

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Chlorphenamine

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Blockers Amiloride Benzamil Triamterene Activators Solnatide...

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