Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver.[1][2] Amiloride is classified as a potassium-sparing diuretic. Amiloride is often used together with another diuretic, such as a thiazide or loop diuretic.[2] It is taken by mouth.[1] Onset of action is about two hours and it lasts for about a day.[2]
Common side effects include high blood potassium, vomiting, loss of appetite, rash, and headache.[1] The risk of high blood potassium is greater in those with kidney problems, diabetes, and those who are older.[1] Amiloride blocks the epithelial sodium channel (ENaC) in the late distal tubule, connecting tubule, and collecting duct of the nephron,[3] which both reduces absorption of sodium ion from the lumen of the nephron and reduces excretion of potassium ion into the lumen.[2]
Amiloride was developed in 1967.[4] It is on the World Health Organization's List of Essential Medicines.[5]
^ abcd"Amiloride Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 27 December 2016. Retrieved 8 December 2016.
^ abcdWorld Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 328, 330. hdl:10665/44053. ISBN 9789241547659.
^Nesterov V, Dahlmann A, Krueger B, Bertog M, Loffing J, Korbmacher C (November 2012). "Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron". American Journal of Physiology. Renal Physiology. 303 (9): F1289–F1299. doi:10.1152/ajprenal.00247.2012. PMID 22933298.
^Progress in Drug Research/Fortschritte der Arzneimittelforschung/Progrés des recherches pharmaceutiques. Birkhäuser. 2013. p. 210. ISBN 9783034870948. Archived from the original on 2016-12-28.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
Amiloride, sold under the trade name Midamor among others, is a medication typically used with other medications to treat high blood pressure or swelling...
or benzyl amiloride is a potent blocker of the ENaC channel and also a sodium-calcium exchange blocker. It is a potent analog of amiloride, and is marketed...
diabetes insipidus. Amiloride has additional benefit of blocking Na uptake. Thiazide diuretics are sometimes combined with amiloride to prevent hypokalemia...
The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable...
potassium canreonate.[citation needed] Epithelial sodium channel blockers: amiloride and triamterene.[citation needed] The term "calcium-sparing diuretic"...
and responses to sodium chloride in the chorda tympani is mediated by amiloride-sensitive sodium channels. The chorda tympani has a relatively low response...
Aylesford School – Sports College, a secondary school in Kent, England The amiloride sensitive sodium channel, also called Epithelial sodium channel (ENaC)...
Spironolactone (or other distal-tubule diuretics, such as triamterene and amiloride) is the drug of choice, because it blocks the aldosterone receptor in...
Alcohol based hand rub Chlorine base compound Chloroxylenol Glutaral Amiloride Furosemide Hydrochlorothiazide Mannitol Spironolactone Complementary:...
the epithelial sodium channel in the distal tubule, thus acting like amiloride. This can cause increased potassium levels in the body (hyperkalemia)...
cell into the forming urine. Blocking ENaC prevents this from happening. Amiloride works in the same way. Sodium channel blockers directly inhibit the entry...
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