An atypical antidepressant is any antidepressant medication that acts in a manner that is different from that of most other antidepressants. Atypical antidepressants include agomelatine, bupropion, iprindole, mianserin, mirtazapine, nefazodone, opipramol, tianeptine, and trazodone.[1][2][3] The agents vilazodone and vortioxetine are partly atypical. Typical antidepressants include the SSRIs, SNRIs, TCAs, and MAOIs, which act mainly by increasing the levels of the monoamine neurotransmitters serotonin and/or norepinephrine.[1][2][3] Among TCAs, trimipramine is an atypical agent in that it appears not to do this.[3] In August 2020, esketamine (JNJ-54135419) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of treatment-resistant depression with the added indication for the short-term treatment of suicidal thoughts.[4]
Buprenorphine/samidorphan (ALKS-5461) is an antidepressant with a novel mechanism of action which was formerly under development and considered an atypical antidepressant.[5] They act faster than available antidepressants.[5]
An atypicalantidepressant is any antidepressant medication that acts in a manner that is different from that of most other antidepressants. Atypical antidepressants...
related to Antidepressants. Management of depression Depression in childhood and adolescence Antidepressants in Japan Atypicalantidepressant Depression...
Celexa (citalopram) – an antidepressant of the SSRI class Centrax (prazepam) – an anti-anxiety agent Clozaril (clozapine) – atypical antipsychotic used to...
approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers...
shown to be of superior efficacy compared to other antidepressants for the treatment of atypical depression, and were used as first-line treatment for...
and sold under the brand name Wellbutrin among others, is an atypicalantidepressant primarily used to treat major depressive disorder and to support...
under the brand names Valdoxan and Thymanax, among others, is an atypicalantidepressant most commonly used to treat major depressive disorder and generalized...
secondary amines Quetiapine (Seroquel) - an atypical antipsychotic sometimes used as an adjunct antidepressant Benzoctamine (Tacitin) – a tetracyclic compound...
brand names Serzone, Dutonin, and Nefadar among others, is an atypicalantidepressant medication which is used in the treatment of depression and for...
disinhibitor (NDDI) Tetracyclic antidepressant Norepinephrine–dopamine reuptake inhibitor Atypicalantidepressant Robert M. Julien (17 September 2004)...
particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypicalantidepressants like bupropion, agomelatine, and...
Mianserin, sold under the brand name Tolvon among others, is an atypicalantidepressant that is used primarily in the treatment of depression in Europe...
Mirtazapine, sold under the brand name Remeron among others, is an atypical tetracyclic antidepressant, and as such is used primarily to treat depression. Its effects...
derived via altering the chemical structure of the tetracyclic (atypical) antidepressant, mianserin. It was initially approved in the United States in 2009...
option is to augment the atypicalantidepressant bupropion to the SSRI as an adjunctive treatment. Venlafaxine, an antidepressant with a different mechanism...
brand names Stablon, Tatinol, and Coaxil among others, is an atypical tricyclic antidepressant which is used mainly in the treatment of major depressive...
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were...
Association (2013). "Vortioxetine: Atypicalantidepressant". Los Angeles Times (2013). "FDA approves a new antidepressant: Brintellix". Los Angeles Times...
other antidepressants, although the quality of many comparisons was assessed as low or very low. Venlafaxine was similar in efficacy to the atypical antidepressant...
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), are a group of antipsychotic...
Etoperidone, associated with several brand names, is an atypicalantidepressant which was developed in the 1970s and either is no longer marketed or was...
under the brand name Survector among others, is an atypicalantidepressant of the tricyclic antidepressant (TCA) family. It acts as a selective and mixed...
of atypical antipsychotics when the patient has not responded to an antidepressant is also known to increase the effectiveness of antidepressant drugs...
Atypical trigeminal neuralgia (ATN), or type 2 trigeminal neuralgia, is a form of trigeminal neuralgia, a disorder of the fifth cranial nerve. This form...
55–56. PMID 16281382. Avdulov NA, Maĭsov NI (November 1981). "[Atypicalantidepressants: effect on synaptosomal uptake of serotonin and GABA]". Biulleten'...
have largely been replaced by z-drugs (zopiclone, zolpidem) and atypicalantidepressants (trazodone, mirtazapine) as first line treatment for insomnia....
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