Transmembrane domain of ABC transporters information
Main transmembrane structural unit of ATP-binding cassette transporter proteins
ABC transporter transmembrane region
Identifiers
Symbol
ABC_membrane
Pfam
PF00664
InterPro
IPR011527
PROSITE
PDOC00364
SCOP2
1pf4 / SCOPe / SUPFAM
TCDB
3.A.1
OPM superfamily
17
OPM protein
2hyd
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
ABC transporter transmembrane domain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family (Pfam PF00005) have two such regions.[1][2][3][4][5][6]
This family appears to correspond to ABC1 by TCDB classification.
^Kerr ID (2002). "Structure and association of ATP-binding cassette transporter nucleotide-binding domains". Biochim. Biophys. Acta. 1561 (1): 47–64. doi:10.1016/s0304-4157(01)00008-9. PMID 11988180. S2CID 7058003.
^Hunt JF, Yuan YR, Martsinkevich O, Millen L, Thomas PJ, Karpowich N, Dai PL, MacVey K (2001). "Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter". Structure. 9 (7): 571–86. doi:10.1016/S0969-2126(01)00617-7. PMID 11470432.
^Hunt JF, Yuan YR, Blecker S, Martsinkevich O, Millen L, Thomas PJ (2001). "The crystal structure of the MJ0796ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter". J. Biol. Chem. 276 (34): 32313–21. doi:10.1074/jbc.M100758200. PMID 11402022.
^Kim SH, Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF (1998). "Crystal structure of the ATP-binding subunit of an ABC transporter". Nature. 396 (6712): 703–707. Bibcode:1998Natur.396..703H. doi:10.1038/25393. PMID 9872322. S2CID 204996524.
^Welte W, Breed J, Boos W, Diederichs K, Vonrhein C, Muller C, Diez J, Greller G, Schnell C (2000). "Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon Thermococcus litoralis". EMBO J. 19 (22): 5951–61. doi:10.1093/emboj/19.22.5951. PMC 305842. PMID 11080142.
^Wiley DC, Gaudet R (2001). "Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing". EMBO J. 20 (17): 4964–72. doi:10.1093/emboj/20.17.4964. PMC 125601. PMID 11532960.
and 23 Related for: Transmembrane domain of ABC transporters information
ABCtransportertransmembranedomain is the main transmembrane structural unit of ATP-binding cassette transporter proteins, consisting of six alpha helixes...
ABCtransporters, ATP synthase (ATP)-binding cassette transporters are a transport system superfamily that is one of the largest and possibly one of the...
A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane. Many transmembrane proteins function as gateways...
hydrophobic transmembranedomains that create the "pore" component. In broad terms, ABCtransporters are involved in the import or export of molecules across...
to the second transmembranedomain by a regulatory "R" domain that is a unique feature of CFTR, not present in other ABCtransporters which carries 19...
atypical SLCs are secondary active or facilitative transporters in humans. Collectively membrane transporters and channels are known as the transportome. Transportomes...
different types oftransporters including pumps, uniporters, antiporters, and symporters. Active transporters or ion pumps are transporters that convert...
superfamily ofABCtransporters. Each channel has two transmembranedomains and two nucleotide binding domains. ATP binding to both nucleotide binding domains causes...
Flippases are transmembrane lipid transporter proteins located in the membrane. They are responsible for aiding the movement of phospholipid molecules...
topologies, suggesting they have ~10 transmembrane (TM) domains. A conserved domain is found at the C terminus of many bicarbonate transport proteins....
protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across...
protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across...
and the transmembranedomain (TMD) are the most conserved region of the transporter in various animal groups, highlighting the importance of these regions...
Members of this protein family have been assigned as thiamine transporters by a phylogenomic analysis of families of genes regulated by the THI element...
possess twelve transmembrane spanners and may also have arisen by a tandem gene duplication event. Structurally, the Ars pumps resemble ABC-type efflux pumps...
membrane-spanning domain that sets it apart from other transporters within the ATP-binding cassette family oftransporters. The two nucleotide binding domains have...
Energization of Outer Membrane Receptor (OMR)-mediated Active Transport 3.A.1 ABCtransporters including BtuCD, molybdate uptake transporter, Cystic fibrosis...
second substrate. The basic fold of the MFS transporter is built around 12, or in some cases, 14 transmembrane helices (TMH), with two 6- (or 7- ) helix...
into prokaryotic cells by one of two types of high-affinity transport systems. The first method involves ABC-type transporters (discussed in this article)...
member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions...
upstream of sterolin-1 in the opposite orientation. Typical ABCtransporter consists of two transmembranedomains and two nucleotide-binding domains. However...
complex, consisting of TAP1 (ABCB2) and TAP2 (ABCB3) members of the ABCtransporter superfamily. The common feature of all ABCtransporters is their organization:...
Global Information