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Tolibut information


Tolibut
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • 4-Amino-3-(4-methylphenyl)butanoic acid
CAS Number
  • 28311-38-8
    28311-37-7 (HCl)
PubChem CID
  • 49344
ChemSpider
  • 44852
UNII
  • UJ5N9SJ9NL
CompTox Dashboard (EPA)
  • DTXSID00951003 Edit this at Wikidata
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CC1=CC=C(C=C1)C(CC(=O)O)CN
InChI
  • InChI=1S/C11H15NO2/c1-8-2-4-9(5-3-8)10(7-12)6-11(13)14/h2-5,10H,6-7,12H2,1H3,(H,13,14)
  • Key:MSZRPURXKHMSFF-UHFFFAOYSA-N

Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia.[1][2][3][4]

  1. ^ Tyurenkov IN, Borodkina LE, Bagmetova VV (September 2012). "Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock". Bulletin of Experimental Biology and Medicine. 153 (5): 710–713. doi:10.1007/s10517-012-1806-5. PMID 23113265. S2CID 767044.
  2. ^ Morozov IS, Kovalev GI, Maisov NI, Kovalev GV, Raevskii KS (January 1977). "Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain". Pharmaceutical Chemistry Journal. 11 (1): 10–12. doi:10.1007/BF00779108. S2CID 27281385.
  3. ^ Dmitriev AV, Andreev NI (1987). "[The spectrum of analgesic activity of baclofen and tolibut]". Farmakologiia I Toksikologiia (in Russian). 50 (1): 24–27. PMID 3556547.
  4. ^ Artem'ev II, Darinskiĭ I, Sologub MI (1992). "[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (1): 16–18. PMID 1363942.

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Tolibut

Last Update:

Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric...

Word Count : 247

C11H15NO2

Last Update:

3-MDMA) 3,4-Methylenedioxyphentermine 2-Methyl-MDA 5-Methyl-MDA 6-Methyl-MDA Tolibut This set index page lists chemical structure articles associated with the...

Word Count : 90

Phenibut

Last Update:

(β-(4-chlorophenyl)-GABA), 4-fluorophenibut (β-(4-fluorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), pregabalin ((S)-β-isobutyl-GABA), gabapentin...

Word Count : 2541

Pentobarbital

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 1924

Promethazine

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 2670

Dimenhydrinate

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 1350

Psychiatry

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 10343

Doxylamine

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 3073

Cannabis

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 9679

Penicillin

Last Update:

Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Positive modulators: ADX-71441 BHF-177 BHFF BSPP CGP-7930 CGP-13501 GS-39783...

Word Count : 10473

Zolpidem

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 5803

Amitriptyline

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 8657

Barbiturate

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 4697

Lorazepam

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 8518

Hydroxyzine

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 3708

Methaqualone

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 2475

Mirtazapine

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 7607

RDX

Last Update:

Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Positive modulators: ADX-71441 BHF-177 BHFF BSPP CGP-7930 CGP-13501 GS-39783...

Word Count : 5907

Ciprofloxacin

Last Update:

Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Positive modulators: ADX-71441 BHF-177 BHFF BSPP CGP-7930 CGP-13501 GS-39783...

Word Count : 6688

Phenobarbital

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 4935

Flunitrazepam

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 3691

Psychoactive drug

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 6249

Xylazine

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 3974

Midazolam

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 6712

Kava

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 7995

Bromazolam

Last Update:

4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...

Word Count : 2075

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