Chemical compound
Tolibut ATC code
4-Amino-3-(4-methylphenyl)butanoic acid
CAS Number 28311-38-8 28311-37-7 (HCl)PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) DTXSID00951003 Formula C 11 H 15 N O 2 Molar mass 193.246 g·mol−1 3D model (JSmol)
CC1=CC=C(C=C1)C(CC(=O)O)CN
InChI=1S/C11H15NO2/c1-8-2-4-9(5-3-8)10(7-12)6-11(13)14/h2-5,10H,6-7,12H2,1H3,(H,13,14)
Key:MSZRPURXKHMSFF-UHFFFAOYSA-N
Tolibut , also known as 3-(p -tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA ), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia.[1] [2] [3] [4]
^ Tyurenkov IN, Borodkina LE, Bagmetova VV (September 2012). "Functional aspects of neuroprotective effects of new salts and compositions of baclofen in the convulsive syndrome caused by electroshock". Bulletin of Experimental Biology and Medicine . 153 (5): 710–713. doi:10.1007/s10517-012-1806-5. PMID 23113265. S2CID 767044.
^ Morozov IS, Kovalev GI, Maisov NI, Kovalev GV, Raevskii KS (January 1977). "Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain". Pharmaceutical Chemistry Journal . 11 (1): 10–12. doi:10.1007/BF00779108. S2CID 27281385.
^ Dmitriev AV, Andreev NI (1987). "[The spectrum of analgesic activity of baclofen and tolibut]". Farmakologiia I Toksikologiia (in Russian). 50 (1): 24–27. PMID 3556547.
^ Artem'ev II, Darinskiĭ I, Sologub MI (1992). "[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (1): 16–18. PMID 1363942.
Last Update: 2024-03-21T16:13:14Z
Tolibut , also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric...
Word Count : 247
Last Update: 2023-02-01T14:53:38Z
3-MDMA) 3,4-Methylenedioxyphentermine 2-Methyl-MDA 5-Methyl-MDA 6-Methyl-MDA Tolibut This set index page lists chemical structure articles associated with the...
Word Count : 90
Last Update: 2024-04-17T22:24:16Z
(β-(4-chlorophenyl)-GABA), 4-fluorophenibut (β-(4-fluorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), pregabalin ((S)-β-isobutyl-GABA), gabapentin...
Word Count : 2541
Last Update: 2024-04-11T21:51:06Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 1924
Last Update: 2024-04-26T11:20:50Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 2670
Last Update: 2024-03-16T19:24:56Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 1350
Last Update: 2024-04-03T19:44:29Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 10343
Last Update: 2024-01-22T04:39:46Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 3073
Last Update: 2024-04-24T18:32:19Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 9679
Last Update: 2024-04-15T13:40:29Z
Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Positive modulators: ADX-71441 BHF-177 BHFF BSPP CGP-7930 CGP-13501 GS-39783...
Word Count : 10473
Last Update: 2024-03-10T06:58:26Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 5803
Last Update: 2024-04-20T06:44:07Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 8657
Last Update: 2024-04-25T03:57:24Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 4697
Last Update: 2024-04-21T16:20:53Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 8518
Last Update: 2024-04-19T17:28:13Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 3708
Last Update: 2024-04-22T18:37:51Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 2475
Last Update: 2024-04-22T13:01:39Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 7607
Last Update: 2024-03-06T17:23:05Z
Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Positive modulators: ADX-71441 BHF-177 BHFF BSPP CGP-7930 CGP-13501 GS-39783...
Word Count : 5907
Last Update: 2024-04-21T01:51:49Z
Phenibut Picamilon Progabide Sodium oxybate SKF-97,541 SL 75102 Tolgabide Tolibut Positive modulators: ADX-71441 BHF-177 BHFF BSPP CGP-7930 CGP-13501 GS-39783...
Word Count : 6688
Last Update: 2024-03-22T15:00:07Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 4935
Last Update: 2024-03-15T21:44:45Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 3691
Last Update: 2024-04-20T10:14:37Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 6249
Last Update: 2024-04-15T23:54:37Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 3974
Last Update: 2024-04-28T08:09:04Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 6712
Last Update: 2024-04-17T09:07:27Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 7995
Last Update: 2024-04-16T18:54:51Z
4-Fluorophenibut Aceburic acid Baclofen GABOB GHB (sodium oxybate) GBL GVL Phenibut Tolibut H1 α2-Adrenergic Clonidine Detomidine Dexmedetomidine Lofexidine Medetomidine...
Word Count : 2075