Crystallographic structure of junctional adhesion molecules linked together
Identifiers
Symbol
JAM
Membranome
Immunoglobulinset domain V set domain
A junctional adhesion molecule (JAM) is a protein that is a member of the immunoglobulin superfamily,[1][2] and is expressed in a variety of different tissues, such as leukocytes, platelets, and epithelial and endothelial cells.[2] They have been shown to regulate signal complex assembly on both their cytoplasmic and extracellular domains through interaction with scaffolding that contains a PDZ domain and adjacent cell's receptors, respectively.[3] JAMs adhere to adjacent cells through interactions with integrins LFA-1 and Mac-1, which are contained in leukocyte β2 and α4β1, which is contained in β1. JAMs have many influences on leukocyte-endothelial cell interactions, which are primarily moderated by the integrins discussed above.[4] They interact in their cytoplasmic domain with scaffold proteins that contain a PDZ domain, which are common protein interaction modules that target short amino acid sequences at the C-terminus of proteins, to form tight junctions in both epithelial and endothelial cells as polarity is gained in the cell.[3]
^Greene C, Campbell M, Janigro D (January 2019). "Chapter 1 - Fundamentals of Brain–Barrier Anatomy and Global Functions". In Lonser RR, Sarntinoranont M, Bankiewicz K (eds.). Nervous System Drug Delivery. Academic Press. pp. 3–20. doi:10.1016/b978-0-12-813997-4.00001-3. ISBN 978-0-12-813997-4. S2CID 198273920.
^ abEbnet K, Suzuki A, Ohno S, Vestweber D (January 2004). "Junctional adhesion molecules (JAMs): more molecules with dual functions?". Journal of Cell Science. 117 (Pt 1): 19–29. doi:10.1242/jcs.00930. PMID 14657270.
^ abEbnet K (October 2017). "Junctional Adhesion Molecules (JAMs): Cell Adhesion Receptors With Pleiotropic Functions in Cell Physiology and Development". Physiological Reviews. 97 (4): 1529–1554. doi:10.1152/physrev.00004.2017. PMID 28931565. S2CID 10846721.
^Lee HJ, Zheng JJ (May 2010). "PDZ domains and their binding partners: structure, specificity, and modification". Cell Communication and Signaling. 8 (1): 8. doi:10.1186/1478-811X-8-8. PMC 2891790. PMID 20509869.
and 25 Related for: Junctional adhesion molecule information
A junctionaladhesionmolecule (JAM) is a protein that is a member of the immunoglobulin superfamily, and is expressed in a variety of different tissues...
Cell adhesionmolecules (CAMs) are a subset of cell surface proteins that are involved in the binding of cells with other cells or with the extracellular...
Cell junctions or junctional complexes are a class of cellular structures consisting of multiprotein complexes that provide contact or adhesion between...
Junctionaladhesionmolecule A is a protein that in humans is encoded by the F11R gene. It has also been designated as CD321 (cluster of differentiation...
Mori, H.; Hata, Y. (15 June 2003). "JAM4, a Junctional Cell AdhesionMolecule Interacting with a Tight Junction Protein, MAGI-1". Molecular and Cellular...
glycoprotein (MAG, SIGLEC-4), CD22 and CD83 CTX family including CTX, Junctionaladhesionmolecule (JAM), BT-IgSF, Coxsackie virus and adenovirus receptor (CAR)...
JAML or JunctionalAdhesionMolecule-Like, or AMICA1 is a JAM transmembrane protein family member. It is composed of two extracellular immunoglobulin-like...
Junctionaladhesionmolecule B is a protein that in humans is encoded by the JAM2 gene. JAM2 has also been designated as CD322 (cluster of differentiation...
Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can...
Epithelial cell adhesionmolecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic...
Junctionaladhesionmolecule C is a protein that in humans is encoded by the JAM3 gene. This gene is located on the long arm of chromosome 11 (11q25) on...
Nectins and Nectin-like molecules (Necl) are families of cellular adhesionmolecules involved in Ca2+-independent cellular adhesion. Nectins are ubiquitously...
Platelet endothelial cell adhesionmolecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the...
of tight junctions and play a significant role in the tight junction's ability to seal the paracellular space. JunctionalAdhesionMolecules (JAM) are...
Orsenigo F, Dejana E, Bazzoni G (March 2001). "Association of junctionaladhesionmolecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2)...
(MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctionaladhesionmolecule". J. Biol. Chem. 277 (1): 455–61...
inheritance pattern in this condition. [citation needed] Another gene junctionaladhesionmolecule 2 (JAM2) has been associated with an autosomal recessive form...
Cell adhesionmolecule 1 is a protein that, in humans, is encoded by the CADM1 gene. Cell adhesionmolecule 1 has been shown to interact with EPB41L3....
ITSN1: encoding protein intersectin-1 JAM2: encoding protein junctionaladhesionmolecule B KCNE1: encoding potassium voltage-gated channel, Isk-related...
(July 1998). "Junctionaladhesionmolecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates...
or as spots of attachment to the extracellular matrix (focal adhesion). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the...
Meyer Zu Brickwedde MK, Pendl GG, Vestweber D (Sep 2000). "Junctionaladhesionmolecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1"...
Freeth J, Smith AW, Green KY (2017). "Identification of human junctionaladhesionmolecule-1 as a functional receptor for the Hom-1 calicivirus on humans...
The following is a list of human clusters of differentiation (or CD) molecules. * = group; ** = not listed on hcdm Bennett JS. Structure and function...
Global Information