CLDN1 information

CLDN1
Identifiers
Aliases	CLDN1, CLD1, ILVASC, SEMP1, claudin 1
External IDs	OMIM: 603718; MGI: 1276109; HomoloGene: 9620; GeneCards: CLDN1; OMA:CLDN1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	190,322,446 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	26,190,591 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; germinal epithelium; ; skin of hip; ; skin of abdomen; ; olfactory zone of nasal mucosa; ; epithelium of nasopharynx; ; left uterine tube; ; right lobe of liver; ; nipple; ; gingival epithelium;
	Top expressed in
	retinal pigment epithelium; ; decidua; ; molar; ; skin of external ear; ; lip; ; Epithelium of choroid plexus; ; epidermis; ; hair follicle; ; skin of abdomen; ; lumbar spinal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; structural molecule activity; identical protein binding; virus receptor activity;
Cellular component	membrane; integral component of membrane; cell junction; plasma membrane; integral component of plasma membrane; apical plasma membrane; lateral plasma membrane; bicellular tight junction; cytoplasm; basolateral plasma membrane;
Biological process	viral entry into host cell; cell-cell junction organization; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; viral process; protein homooligomerization; protein heterooligomerization; establishment of skin barrier; bicellular tight junction assembly; human ageing; establishment of blood-nerve barrier; response to toxic substance; response to lipopolysaccharide; hyperosmotic salinity response; response to ethanol; xenobiotic transport across blood-nerve barrier; response to interleukin-18; cellular response to lead ion; cellular response to interferon-gamma; cellular response to tumor necrosis factor; response to dexamethasone; cellular response to transforming growth factor beta stimulus; establishment of endothelial intestinal barrier; liver regeneration; positive regulation of bicellular tight junction assembly; cellular response to butyrate;
	Sources:Amigo / QuickGO
Orthologs
	9076
	12737
	ENSG00000163347
	ENSMUSG00000022512
	O95832
	O88551
	NM_021101
	NM_016674
	NP_066924
	NP_057883
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-1 is a protein that in humans is encoded by the CLDN1 gene.^[5]^[6] It belongs to the group of claudins.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163347 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022512 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Halford S, Spencer P, Greenwood J, Winton H, Hunt DM, Adamson P (Jun 2000). "Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids". Cytogenet. Cell Genet. 88 (3–4): 217. doi:10.1159/000015553. PMID 10828592. S2CID 8896678.
^ Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163347 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022512 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10828592-5] Halford S, Spencer P, Greenwood J, Winton H, Hunt DM, Adamson P (Jun 2000). "Assignment of claudin-1 (CLDN1) to human chromosome 3q28-->q29 with somatic cell hybrids". Cytogenet. Cell Genet. 88 (3–4): 217. doi:10.1159/000015553. PMID 10828592. S2CID 8896678.

[pmid9892664-6] Morita K, Furuse M, Fujimoto K, Tsukita S (Mar 1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.

CLDN1 information

and 8 Related for: CLDN1 information

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List of OMIM disorder codes