CLDN18 information

CLDN18
Identifiers
Aliases	CLDN18, SFTA5, SFTPJ, claudin 18
External IDs	OMIM: 609210; MGI: 1929209; HomoloGene: 9489; GeneCards: CLDN18; OMA:CLDN18 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	138,033,655 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	99,599,320 bp
RNA expression pattern
	Top expressed in
	pylorus; ; lower lobe of lung; ; cardia; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; body of stomach; ; gastric mucosa; ; visceral pleura; ; fundus;
	Top expressed in
	mucous cell of stomach; ; right lung lobe; ; epithelium of stomach; ; pyloric antrum; ; left lung; ; left lung lobe; ; blastocyst; ; duodenum; ; embryo; ; right kidney;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; identical protein binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; membrane; bicellular tight junction;
Biological process	negative regulation of protein localization to nucleus; TNFSF11-mediated signaling pathway; calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; digestive tract development; negative regulation of osteoclast development; negative regulation of bone resorption; response to ethanol;
	Sources:Amigo / QuickGO
Orthologs
	51208
	56492
	ENSG00000066405
	ENSMUSG00000032473
	P56856
	P56857
	NM_016369; NM_001002026
	NM_001194921; NM_001194922; NM_001194923; NM_019815
	NP_001002026; NP_057453
	NP_001181850; NP_001181851; NP_001181852; NP_062789
	Wikidata
View/Edit Human	View/Edit Mouse

Claudin-18 is a protein that in humans is encoded by the CLDN18 gene.^[5] It belongs to the group of claudins.

CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells .^[6] [supplied by OMIM]^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000066405 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032473 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CLDN18 claudin 18".
^ Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000066405 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032473 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLDN18 claudin 18".

[Niimi2001-6] Niimi T, Nagashima K, Ward JM, et al. (2001). "claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing". Mol. Cell. Biol. 21 (21): 7380–90. doi:10.1128/MCB.21.21.7380-7390.2001. PMC 99911. PMID 11585919.

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