calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
response to hypoxia
protein homooligomerization
epithelial cell morphogenesis
protein heterooligomerization
bicellular tight junction assembly
signal transduction
response to ethanol
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
1365
12739
Ensembl
ENSG00000165215
ENSMUSG00000070473
UniProt
O15551
Q9Z0G9
RefSeq (mRNA)
NM_001306
NM_009902
RefSeq (protein)
NP_001297
NP_034032
Location (UCSC)
Chr 7: 73.77 – 73.77 Mb
Chr 5: 135.02 – 135.02 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene.[5] It is a member of the claudin protein family.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000165215 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000070473 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene. It is a member of the claudin protein family. Tight junctions...
children without the syndrome. Williams syndrome genes ASL BAZ1B BCL7B CLDN3 CLDN4 CLIP2 EIF4H ELN FZD9 FKBP6 GTF2I GTF2IRD1 HIP1 KCTD7 LAT2 LIMK1 MDH2...
cholangitis syndrome. CLDN1 has been shown to interact with CLDN5 and CLDN3. GRCh38: Ensembl release 89: ENSG00000163347 – Ensembl, May 2017 GRCm38:...
velocardiofacial syndrome. CLDN5 has been shown to interact with CLDN1 and CLDN3. GRCh38: Ensembl release 89: ENSG00000184113 – Ensembl, May 2017 GRCm38:...