mitogen-activated protein kinase kinase kinase binding
zinc ion binding
signal transducer activity
metal ion binding
ubiquitin-protein transferase activity
protein binding
identical protein binding
thioesterase binding
enzyme binding
protein phosphatase binding
protein kinase binding
ubiquitin protein ligase binding
transferase activity
tumor necrosis factor receptor binding
protein-containing complex binding
Cellular component
TRAF2-GSTP1 complex
AIP1-IRE1 complex
ubiquitin ligase complex
vesicle membrane
cell cortex
membrane raft
CD40 receptor complex
cytoplasmic side of plasma membrane
IRE1-TRAF2-ASK1 complex
nucleoplasm
cytoplasm
cytosol
protein-containing complex
Biological process
regulation of apoptotic process
positive regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of JUN kinase activity
negative regulation of glial cell apoptotic process
regulation of tumor necrosis factor-mediated signaling pathway
protein K63-linked ubiquitination
positive regulation of DNA-binding transcription factor activity
tumor necrosis factor-mediated signaling pathway
activation of NF-kappaB-inducing kinase activity
positive regulation of protein homodimerization activity
response to endoplasmic reticulum stress
protein homotrimerization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
positive regulation of I-kappaB phosphorylation
regulation of JNK cascade
protein catabolic process
positive regulation of NF-kappaB transcription factor activity
positive regulation of interleukin-2 production
death-inducing signaling complex assembly
positive regulation of T cell cytokine production
protein ubiquitination
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of extrinsic apoptotic signaling pathway
cellular response to nitric oxide
regulation of extrinsic apoptotic signaling pathway via death domain receptors
I-kappaB kinase/NF-kappaB signaling
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
protein autoubiquitination
negative regulation of neuron death
programmed necrotic cell death
apoptotic process
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
protein deubiquitination
protein heterooligomerization
protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7186
22030
Ensembl
ENSG00000127191
ENSMUSG00000026942
UniProt
Q12933
P39429
RefSeq (mRNA)
NM_021138
NM_009422 NM_001290413
RefSeq (protein)
NP_066961
NP_001277342 NP_033448
Location (UCSC)
Chr 9: 136.88 – 136.93 Mb
Chr 2: 25.41 – 25.44 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000127191 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026942 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Song HY, Donner DB (September 1995). "Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor". Biochem J. 309 (Pt 3): 825–9. doi:10.1042/bj3090825. PMC 1135706. PMID 7639698.
receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene. The protein encoded by this gene is a member of the TNF receptor associated...
binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This...
three pathways can be initiated. Activation of NF-κB: TRADD recruits TRAF2 and RIP. TRAF2 in turn recruits the multicomponent protein kinase IKK, enabling...
receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction...
RasMol RasMol ribbon diagram rendering of TRAF2 trimer PDB:1DOA Original author(s) Roger A. Sayle Developer(s) Herbert J. Bernstein Initial release 1992;...
Th2 mediated reactions in vivo. OX40 binds TRAF2, 3 and 5 as well as PI3K by an unknown mechanism. TRAF2 is required for survival via NF-κB and memory...
domain protein (FADD). cIAP1/2 can inhibit TNF-α signaling by binding to TRAF2. FLIP inhibits the activation of caspase-8. Binding of this receptor can...
the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest...
signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2, TRAF3, and TRAF5 have been shown to mediate the signaling process of this...
TRAF2 and NCK-interacting protein kinase is an enzyme that in humans is encoded by the TNIK gene. Germinal center kinases (GCKs), such as TNIK, are characterized...
adherens junctions. TNFAIP3 has been shown to interact with TNIP1, TRAF1, TRAF2, IKBKG, TAX1BP1, YWHAB, YWHAZ, TRAF6 and YWHAH. The TNFAIP3 locus is implicated...
transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation...
TNFR-associated death protein TRADD and TNF receptor-associated factor 2 TRAF2 signals to RIPK1 which recruits RIPK3 forming the necrosome also named ripoptosome...
IRE-1α also recruits tumor necrosis factor receptor-associated factor 2 (TRAF2). This kinase cascade that is dependent on IRE-1α and JNK mediates ER stress–induced...
survival and is important in necroptosis induction. RIP interacts with TRAF2 via the kinase domain. The KD can also interact with Necrostatin-1, which...
a major one, [PSAT]x[QE]E and a minor one, PxQxxD. The structure of the TRAF2 protein reveals a trimeric self-association of the MATH domain. The domain...
atherosclerotic inflammatory lesions. CD137 has been shown to interact with TRAF2. CD137 is also involved in cancer having been found upregulated in cancerous...
kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. A recent study showed...
Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7. Except for TRAF7, these proteins...
Without CD28, OX40 expression is delayed and reduced. OX40 also binds TRAF2, 3 and 5 and PI3K. OX40 gene mutations can cause a type of immunodeficiency...
appear to compete with TNF-α receptor-associated factor 2 (TRAF2), an ASK1 activator. TRAF2 and TRAF6 are then recruited to ASK1 to form a larger molecular...
induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1". The Journal of Biological Chemistry. 284 (16): 10774–10782. doi:10...
platelet-derived growth factor and serum. SPHK1 has been shown to interact with TRAF2. GRCh38: Ensembl release 89: ENSG00000176170 – Ensembl, May 2017 GRCm38:...
When CD40 is stimulated by CD40L, Act1 binds to TRAF3, with the help of TRAF2 and 5 in order to activate the JNK proteins. The precise function of TRAF3...
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