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TNFRSF8
Available structures
PDB
Ortholog search: PDBe RCSB
List of PDB id codes
1D01
Identifiers
Aliases
TNFRSF8, CD30, D1S166E, Ki-1, tumor necrosis factor receptor superfamily member 8, TNF receptor superfamily member 8
dentate gyrus of hippocampal formation granule cell
primary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
transmembrane signaling receptor activity
tumor necrosis factor-activated receptor activity
nerve growth factor binding
Cellular component
cytoplasm
integral component of membrane
integral component of plasma membrane
extracellular exosome
membrane
plasma membrane
nucleus
neuron projection
Biological process
apoptotic signaling pathway
cellular response to mechanical stimulus
response to lipopolysaccharide
inflammatory response
immune response
signal transduction
negative regulation of cell population proliferation
positive regulation of apoptotic process
tumor necrosis factor-mediated signaling pathway
axon guidance
negative regulation of neuron projection development
positive regulation of NF-kappaB transcription factor activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
943
21941
Ensembl
ENSG00000120949
ENSMUSG00000028602
UniProt
P28908
Q60846
RefSeq (mRNA)
NM_001243 NM_001281430 NM_152942
NM_009401
RefSeq (protein)
NP_001234 NP_001268359
NP_033427
Location (UCSC)
Chr 1: 12.06 – 12.14 Mb
Chr 4: 144.99 – 145.04 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
CD30, also known as TNFRSF8 (TNF receptor superfamily member 8),[5] is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker.
^ abcGRCh38: Ensembl release 89: ENSG00000120949 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000028602 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily member 8". National Library of Medicine, National Center for Biotechnology Information. 22 September 2022. Retrieved 6 November 2022.
CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker...
non-Hodgkin lymphoma. It selectively targets tumor cells expressing the CD30 antigen, a defining marker of Hodgkin lymphoma and ALCL. The drug is being...
receptor CD30. It plays a role in the T cell-dependent anti-mycobacterial immune response. Marín ND, García LF (January 2017). "The role of CD30 and CD153...
large cell lymphoma belongs to the group of cutaneous processes that are CD30+ lymphoproliferative and are characterized by autoregressive, recurrent,...
similar to anaplastic large cell lymphoma. Type "A" is CD30 positive, while type "B" is CD30 negative. It has been described as "clinically benign but...
treat cancer. Brentuximab vedotin, for example, links the chimeric anti-CD30 monoclonal antibody (cAC10) via a protease-cleavable linker to MMAE. This...
antibodies (usually forming an antibody-drug conjugate). targeting the protein CD30 which is found on malignant cells in anaplastic large cell lymphoma and Hodgkin's...
large often bi-nucleated cells with prominent nucleoli and an unusual CD45−, CD30+, CD15+/− immunophenotype. In approximately 50% of cases, the Reed–Sternberg...
in the lesion exhibit hypertrophy. In transformed cells, presence of the CD30 receptor is associated with improved survival To stage the disease, various...
classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20. The anti-CD20 monoclonal...
presence of clusters of differentiation, cell surface proteins – namely CD30, with CD19, CD20 and CD22, and with the absence of CD15. Other markers may...
domain, and includes several other non-cytokine ligands like CD40, CD27 and CD30, besides the ligands on which the family is named. Seven transmembrane helix...
mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in...
includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is named (TNF). Chemokine receptors...
Global Information
