negative regulation of DNA-binding transcription factor activity
multicellular organism development
T cell proliferation
response to lipopolysaccharide
regulation of cell population proliferation
positive regulation of B cell proliferation
immune response
apoptotic signaling pathway
viral entry into host cell
inflammatory response
negative regulation of transcription, DNA-templated
viral process
cellular defense response
regulation of protein kinase activity
negative regulation of activation-induced cell death of T cells
negative regulation of extrinsic apoptotic signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7293
22163
Ensembl
ENSG00000186827
n/a
UniProt
P43489
P47741
RefSeq (mRNA)
NM_003327
NM_011659
RefSeq (protein)
NP_003318
NP_035789
Location (UCSC)
Chr 1: 1.21 – 1.21 Mb
n/a
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which is not constitutively expressed on resting naïve T cells, unlike CD28. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation. Expression of OX40 is dependent on full activation of the T cell; without CD28, expression of OX40 is delayed and of fourfold lower levels.
^ abcGRCh38: Ensembl release 89: ENSG00000186827 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor, is a member of the TNFR-superfamily of receptors which...
OX40L is the ligand for OX40 (also known as CD134 or TNFRSF4) and is stably expressed on many antigen-presenting cells such as DC2s (a subtype of dendritic...
the target cells' surface receptors. First, the SU glycoprotein binds to CD134, a receptor on the host cell. This initial binding changes the shape of...
by expression of CD39 in combination with co-expression of CD25 and OX40(CD134) which define antigen-specific cells following 24-48h stimulation with antigen...
Global Information
