regulation of tumor necrosis factor-mediated signaling pathway
regulation of extrinsic apoptotic signaling pathway
signal transduction
apoptotic process
positive regulation of NF-kappaB transcription factor activity
protein-containing complex assembly
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
7185
22029
Ensembl
ENSG00000056558
ENSMUSG00000026875
UniProt
Q13077
P39428
RefSeq (mRNA)
NM_005658 NM_001190945 NM_001190947
NM_009421 NM_001326601
RefSeq (protein)
NP_001177874 NP_001177876 NP_005649
NP_001313530 NP_033447
Location (UCSC)
Chr 9: 120.9 – 120.93 Mb
Chr 2: 34.83 – 34.85 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000056558 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026875 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Rothe M, Wong SC, Henzel WJ, Goeddel DV (September 1994). "A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor". Cell. 78 (4): 681–92. doi:10.1016/0092-8674(94)90532-0. PMID 8069916. S2CID 28055231.
receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR)...
physical activity) Overweight and obese Genetic factors such as HLA-DR1B1, TRAF1, PSORS1C1 and microRNA 146a are associated with difficult to treat rheumatoid...
phosphorylation of the TNF receptor-associated factor (TRAF1) on serine 139 under specific conditions. Murine TRAF1 is also phosphorylated by the same kinase, which...
domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction...
endothelial adherens junctions. TNFAIP3 has been shown to interact with TNIP1, TRAF1, TRAF2, IKBKG, TAX1BP1, YWHAB, YWHAZ, TRAF6 and YWHAH. The TNFAIP3 locus...
NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence...
apoptosis. Currently, seven TRAF proteins have been characterized in mammals: TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6 and TRAF7. Except for TRAF7, these proteins...
Thukral S, Mak TW (Apr 1997). "Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily". Biochemical...
activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as...
signaling is propagated via recruiting TRAF-family members, specifically TRAF1, TRAF2 and TRAF5, to the GITR-signaling complex. The signaling is then mediated...
defective coupling between the two. RANK has been shown to interact with: TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6. RANKL Osteoprotegerin Osteoimmunology GRCh38:...
OMIM] It regulates osteoblasts. HIVEP3 has been shown to interact with TRAF1 and TRAF2. GRCh38: Ensembl release 89: ENSG00000127124 – Ensembl, May 2017...