cysteine-type endopeptidase inhibitor activity involved in apoptotic process
protein binding
transmembrane signaling receptor activity
Cellular component
extracellular region
integral component of membrane
integral component of plasma membrane
membrane
cell surface
plasma membrane
external side of plasma membrane
Biological process
negative regulation of apoptotic process
response to lipopolysaccharide
response to ethanol
negative regulation of T cell apoptotic process
extrinsic apoptotic signaling pathway
regulation of cell population proliferation
cell surface receptor signaling pathway
apoptotic process
tumor necrosis factor-mediated signaling pathway
immunoglobulin mediated immune response
positive regulation of JNK cascade
inflammatory response
immune response
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of B cell differentiation
positive regulation of T cell differentiation
multicellular organism development
positive regulation of NIK/NF-kappaB signaling
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
939
21940
Ensembl
ENSG00000139193
ENSMUSG00000030336
UniProt
P26842
P41272
RefSeq (mRNA)
NM_001242
NM_001033126 NM_001042564 NM_001286753
RefSeq (protein)
NP_001233
NP_001028298 NP_001036029 NP_001273682
Location (UCSC)
Chr 12: 6.44 – 6.45 Mb
Chr 6: 125.21 – 125.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
CD27 is a member of the tumor necrosis factor receptor superfamily.[5] It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000139193 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000030336 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Buchan SL, Rogel A, Al-Shamkhani A (January 2018). "The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy". Blood. 131 (1): 39–48. doi:10.1182/blood-2017-07-741025. PMID 29118006.
^Sturgill ER (November 2017). "TNFR agonists: a review of current biologics targeting OX40, 4-1BB, CD27, and GITR". American Journal of Hematology/Oncology. 13 (11): 4–15.
CD27 is a member of the tumor necrosis factor receptor superfamily. It is currently of interest to immunologists as a co-stimulatory immune checkpoint...
that in humans is encoded by CD70 gene. CD70 is also known as a ligand for CD27. In physiological condition the expression of CD70 on immune cells is transient...
superfamily—CD27, CD40, OX40, GITR and CD137. Another two stimulatory checkpoint molecules belong to the B7-CD28 superfamily—CD28 itself and ICOS. CD27: This...
receptor. In humans, CD27 is a good marker for plasma cells; naïve B cells are CD27−, memory B-cells are CD27+ and plasma cells are CD27++. The surface antigen...
promote the secretion of immunoglobulins though CD27/CD70 interactions. B cells begin expressing CD27 at the beginning of the centroblast stage and lose...
distinguished by the cell surface marker CD27, although some subsets do not express CD27. Memory B cells that lack CD27 are generally associated with exhausted...
domain, and includes several other non-cytokine ligands like receptors, CD40, CD27 and CD30, besides the ligands on which the family is named (TNF). Chemokine...
immunotherapy for solid tumors and hematologic malignancies. It is an anti-CD27 antibody and helps activate T-cells. This drug was developed by Celldex Therapeutics...
binding domain, and includes several other non-cytokine ligands like CD40, CD27 and CD30, besides the ligands on which the family is named. Seven transmembrane...
immature B cells. Memory B cells with increased CD27+/IgD—are less susceptible to immunosuppression. CD27-/IgD- memory B cells are associated with increased...
bone marrow. Human B1 cells have been found to have marker profile of CD20+CD27+CD43+CD70- and could either be CD5+ or CD5-, which has been debated since...
naive T cells, TSCM cells are CD45RO−, CCR7+, CD45RA+, CD62L+ (L-selectin), CD27+, CD28+, and IL-7Rα+, but they also express large amounts of CD95, IL-2Rβ...
genes: UNC13D, STX11, RAB27A, STXBP2, LYST, PRF1 1, SH2D1A, BIRC4, ITK, CD27, and MAGT1. Secondary HLH (sHLH) is associated with, and thought to be promoted...
expressing both naïve T cells markers, such as CD45RA+, CD45RO-, high levels of CD27, CD28, IL-7Rα (CD127), CD62L, and C-C chemokine receptor 7 (CCR7), as well...
B lymphoid progenitors. CD27 plays a role in lymphoid proliferation, differentiation, and apoptosis. The acquisition of CD27 and Flt3 by the HSC coincides...
Global Information
