mitogen-activated protein kinase kinase kinase binding
kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
MAP kinase kinase kinase kinase activity
Cellular component
Golgi apparatus
membrane
Golgi membrane
plasma membrane
basolateral plasma membrane
cytoplasm
Biological process
intracellular signal transduction
vesicle targeting
phosphorylation
immune system process
positive regulation of JNK cascade
protein phosphorylation
JNK cascade
immune response
innate immune response
regulation of mitotic cell cycle
regulation of apoptotic process
signal transduction
stress-activated protein kinase signaling cascade
activation of protein kinase activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5871
26412
Ensembl
ENSG00000168067
ENSMUSG00000024948
UniProt
Q12851
Q61161
RefSeq (mRNA)
NM_001307990 NM_004579
NM_001291787 NM_009006
RefSeq (protein)
NP_001294919 NP_004570
NP_001278716 NP_033032
Location (UCSC)
Chr 11: 64.78 – 64.8 Mb
Chr 19: 6.39 – 6.41 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000168067 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024948 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Katz P, Whalen G, Kehrl JH (Jun 1994). "Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center". The Journal of Biological Chemistry. 269 (24): 16802–9. doi:10.1016/S0021-9258(19)89463-2. PMID 7515885.
^"Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2".
kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene. The protein encoded by this gene is a member of the serine/threonine...
United States Glucokinase Government College, Kattappana, in Kerala, India MAP4K2, an enzyme GC Kompetition, a French motorsport team This disambiguation...
kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK.[citation needed] MKK7 is ubiquitously expressed in all tissue. However...
has a CDC42-binding domain. In contrast, members of the GCK subfamily (MAP4K2), also called the Sps1 subfamily, have an N-terminal catalytic domain and...
chromosome 19p13.1. RAB8A has been shown to interact with Optineurin and MAP4K2. GRCh38: Ensembl release 89: ENSG00000167461 – Ensembl, May 2017 GRCm38:...