Sulpiride information

Sulpiride
Clinical data
Trade names	Dogmatil, others
AHFS/Drugs.com	International Drug Names
Routes of; administration	By mouth (tablets, capsules, solution), intramuscular injection
ATC code	N05AL01 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances); UK: POM (Prescription only); In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	25–40%
Protein binding	<40%
Metabolism	Not metabolized; 95% is exerted as the unchanged drug
Elimination half-life	6–8 hours
Excretion	Urine (70–90%),; Feces.
Identifiers
	IUPAC name N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide;
CAS Number	15676-16-1 ;
PubChem CID	5355;
IUPHAR/BPS	5501;
DrugBank	DB00391 ;
ChemSpider	5162 ;
UNII	7MNE9M8287;
KEGG	D01226 ;
ChEMBL	ChEMBL26 ;
CompTox Dashboard (EPA)	DTXSID1042574 ;
ECHA InfoCard	100.036.124
Chemical and physical data
Formula	C15H23N3O4S
Molar mass	341.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NS(=O)(=O)c1ccc(OC)c(c1)C(=O)NCC1CCCN1CC;
	InChI InChI=1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21) ; Key:BGRJTUBHPOOWDU-UHFFFAOYSA-N ;
	(verify)

Sulpiride, sold under the brand name Dogmatil among others, is an atypical antipsychotic (although some texts have referred to it as a typical antipsychotic)^[10] medication of the benzamide class which is used mainly in the treatment of psychosis associated with schizophrenia and major depressive disorder, and sometimes used in low dosage to treat anxiety and mild depression. Sulpiride is commonly used in Asia, Central America, Europe, South Africa and South America. Levosulpiride is its purified levo-isomer and is sold in India for similar purpose. It is not approved in the United States, Canada, or Australia. The drug is chemically and clinically similar to amisulpride.

^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
^ ^a ^b ^c ^d "Sulpiride Tablets 200mg, 400mg (SPC)". electronic Medicines Compendium (eMC). Sanofi. 21 January 2010. Archived from the original on 19 October 2013. Retrieved 19 October 2013.
^ ^a ^b Bressolle F, Brès J, Fauré-Jeantis A (January 1992). "Absolute bioavailability, rate of absorption, and dose proportionality of sulpiride in humans". Journal of Pharmaceutical Sciences. 81 (1): 26–32. doi:10.1002/jps.2600810106. PMID 1619566.
^ ^a ^b Brès J, Bressolle F (December 1991). "Pharmacokinetics of sulpiride in humans after intravenous and intramuscular administrations". J Pharm Sci. 80 (12): 1119–24. doi:10.1002/jps.2600801206. PMID 1815069.
^ ^a ^b ^c Imondi AR, Alam AS, Brennan JJ, Hagerman LM (March 1978). "Metabolism of sulpiride in man and rhesus monkeys". Archives Internationales de Pharmacodynamie et de Therapie. 232 (1): 79–91. PMID 96745.
^ Niwa T, Inoue S, Shiraga T, Takagi A (January 2005). "No inhibition of cytochrome P450 activities in human liver microsomes by sulpiride, an antipsychotic drug". Biological & Pharmaceutical Bulletin. 28 (1): 188–191. doi:10.1248/bpb.28.188. PMID 15635191.
^ Telles-Correia D, Barbosa A, Cortez-Pinto H, Campos C, Rocha NB, Machado S (February 2017). "Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity". World Journal of Gastrointestinal Pharmacology and Therapeutics. 8 (1): 26–38. doi:10.4292/wjgpt.v8.i1.26. PMC 5292604. PMID 28217372.
^ Lv Q, Yi Z (February 2018). "Antipsychotic Drugs and Liver Injury". Shanghai Archives of Psychiatry. 30 (1): 47–51. PMC 5925599. PMID 29719358.
^ Kobari T, Namekawa H, Kato Y, Yamada S (June 1985). "Biotransformation of sultopride in man and several animal species". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 15 (6): 469–476. doi:10.3109/00498258509045020. PMID 4036171.
^ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.

[1] Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.

[EMC-2] "Sulpiride Tablets 200mg, 400mg (SPC)". electronic Medicines Compendium (eMC). Sanofi. 21 January 2010. Archived from the original on 19 October 2013. Retrieved 19 October 2013.

[Pharm-3] Bressolle F, Brès J, Fauré-Jeantis A (January 1992). "Absolute bioavailability, rate of absorption, and dose proportionality of sulpiride in humans". Journal of Pharmaceutical Sciences. 81 (1): 26–32. doi:10.1002/jps.2600810106. PMID 1619566.

[pmid1815069-4] Brès J, Bressolle F (December 1991). "Pharmacokinetics of sulpiride in humans after intravenous and intramuscular administrations". J Pharm Sci. 80 (12): 1119–24. doi:10.1002/jps.2600801206. PMID 1815069.

[pmid96745-5] Imondi AR, Alam AS, Brennan JJ, Hagerman LM (March 1978). "Metabolism of sulpiride in man and rhesus monkeys". Archives Internationales de Pharmacodynamie et de Therapie. 232 (1): 79–91. PMID 96745.

[NoInhibition-6] Niwa T, Inoue S, Shiraga T, Takagi A (January 2005). "No inhibition of cytochrome P450 activities in human liver microsomes by sulpiride, an antipsychotic drug". Biological & Pharmaceutical Bulletin. 28 (1): 188–191. doi:10.1248/bpb.28.188. PMID 15635191.

[7] Telles-Correia D, Barbosa A, Cortez-Pinto H, Campos C, Rocha NB, Machado S (February 2017). "Psychotropic drugs and liver disease: A critical review of pharmacokinetics and liver toxicity". World Journal of Gastrointestinal Pharmacology and Therapeutics. 8 (1): 26–38. doi:10.4292/wjgpt.v8.i1.26. PMC 5292604. PMID 28217372.

[8] Lv Q, Yi Z (February 2018). "Antipsychotic Drugs and Liver Injury". Shanghai Archives of Psychiatry. 30 (1): 47–51. PMC 5925599. PMID 29719358.

[9] Kobari T, Namekawa H, Kato Y, Yamada S (June 1985). "Biotransformation of sultopride in man and several animal species". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 15 (6): 469–476. doi:10.3109/00498258509045020. PMID 4036171.

[10] Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.

Sulpiride information

and 28 Related for: Sulpiride information

Sulpiride

Levosulpiride

Tiapride

Amisulpride

Modal

Benzamide

List of psychiatric medications

Brazilian Controlled Drugs and Substances Act

Ketamine

Bromazepam

Dopaminergic

Galactagogue

LSD

Apraxia of lid opening

Oxytocin

Prolactin

Phencyclidine

Antipsychotic

Amitriptyline

Metoclopramide

Haloperidol

Metandienone

Galega officinalis

Promethazine

Luteinizing hormone

Clocapramine

Sultopride

Silybum marianum