Karyopherins are proteins involved in transporting molecules between the cytoplasm and the nucleus of a eukaryotic cell. The inside of the nucleus is called the karyoplasm (or nucleoplasm). Generally, karyopherin-mediated transport occurs through nuclear pores which act as a gateway into and out of the nucleus. Most proteins require karyopherins to traverse the nuclear pore.
Karyopherins can act as importins (i.e. helping proteins get into the nucleus) or exportins (i.e. helping proteins get out of the nucleus). They belong to the nuclear pore complex family[1] in the transporter classification database (TCDB). Energy for transport is derived from the Ran gradient.
Upon stress, several karyopherins stop shuttling between the nucleus and the cytoplasm and are sequestered in stress granules, cytoplasmic aggregates of ribonucleoprotein complexes.[2][3]
^"Tcdb » Search".
^Mahboubi, Hicham; Seganathy, Evangeline; Kong, Dekun; Stochaj, Ursula (2013-06-27). "Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport". PLOS ONE. 8 (6): e68356. Bibcode:2013PLoSO...868356M. doi:10.1371/journal.pone.0068356. PMC 3694919. PMID 23826389.
^Fujimura, Ken; Suzuki, Tomonori; Yasuda, Yoshinari; Murata, Masayuki; Katahira, Jun; Yoneda, Yoshihiro (2010-07-01). "Identification of importin α1 as a novel constituent of RNA stress granules". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1803 (7): 865–871. doi:10.1016/j.bbamcr.2010.03.020. PMID 20362631.
Karyopherins are proteins involved in transporting molecules between the cytoplasm and the nucleus of a eukaryotic cell. The inside of the nucleus is called...
allows the protein to bind to Importin β2 (also known as transportin or karyopherin β2), which then translocates the cargo protein into the nucleus. The...
process mediated by a family of transport factors known as karyopherins. Those karyopherins that mediate movement into the nucleus are also called importins...
hydrolase-dependent process. This family is further subdivided to the karyopherin-α and the karyopherin-β subfamilies. Other nuclear transport receptors include NTF2...
protein is a karyopherin which interacts with nuclear localization sequence to target nuclear proteins to the nucleus. The classical karyopherin receptor...
phenomenon can be leveraged towards bio-inspired applications. He studies how karyopherin receptors facilitate this highly rapid and selective process through...
Importin is a type of karyopherin that transports protein molecules from the cell's cytoplasm to the nucleus. It does so by binding to specific recognition...
Blobel G, Radu A (September 1997). "RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153". Proc. Natl...
nucleocytoplasmic shuttler Exportin-5. This protein, a member of the karyopherin family, recognizes a two-nucleotide overhang left by the RNase III enzyme...
anchoring of NPCs. It also acts as the docking site of an importing karyopherin. On the cytoplasmic side of the NPC, Nup358 fulfills an analogous role...
PMC 2132560. PMID 9298975. Shamsher MK, Ploski J, Radu A (October 2002). "Karyopherin beta 2B participates in mRNA export from the nucleus". Proceedings of...
association with transport factors known as nuclear transport receptors, like karyopherins called importins to enter the nucleus and exportins to exit. Protein...
transporter molecules karyopherins. Karyopherins will bind to their cargo, and reversibly interact with the FG repeats in nucleoporins. Karyopherins and their cargo...
necessary for the transport of proteins into and out of the nucleus by karyopherin proteins. In mammalian and plant cells, RanGAP is located at the nuclear...
through the hydrophobic central channel of the nuclear pore complex. The karyopherin Crm1 is the receptor for both ribosomal subunits and mediates export...
of the importin – exportin (karyopherin) family and lack the characteristic Ran-binding domain found in all karyopherins. The ATPase activity of TAP is...
common and reversible modification that impairs the protein's binding of karyopherin beta (Transportin-1) resulting in nuclear localization of hnRNPA1. hnRNP A1...
nucleus. Proteins responsible for nuclear import of H2A protein are karyopherin and importin. Recent studies also show that nucleosome assembly protein...
salivary gland pleomorphic adenomas. PLAG1 has been shown to interact with Karyopherin alpha 2. GRCh38: Ensembl release 89: ENSG00000181690 – Ensembl, May 2017...
Representative examples of HEAT repeat proteins include importin β (also known as karyopherin β) family, regulatory subunits of condensin and cohesin, separase, PIKKs...
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