G3BP1 information

G3BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q90, 4FCJ, 4FCM, 4IIA
Identifiers
Aliases	G3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1
External IDs	OMIM: 608431; MGI: 1351465; HomoloGene: 38096; GeneCards: G3BP1; OMA:G3BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,812,911 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	55,395,664 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; islet of Langerhans; ; stromal cell of endometrium; ; Achilles tendon; ; thymus; ; gastrocnemius muscle; ; rectum; ; lymph node; ; pericardium; ; gallbladder;
	Top expressed in
	corneal stroma; ; plantaris muscle; ; extensor digitorum longus muscle; ; neural tube; ; yolk sac; ; interventricular septum; ; extraocular muscle; ; lip; ; entorhinal cortex; ; spermatocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; DNA helicase activity; protein binding; nucleic acid binding; nuclease activity; endonuclease activity; ATP binding; hydrolase activity; mRNA binding; RNA binding;
Cellular component	membrane; focal adhesion; plasma membrane; intracellular anatomical structure; cytoplasmic stress granule; nucleus; cytoplasm; cytosol; perikaryon; ribonucleoprotein complex;
Biological process	nucleic acid phosphodiester bond hydrolysis; Ras protein signal transduction; negative regulation of canonical Wnt signaling pathway; DNA duplex unwinding; transport; stress granule assembly;
	Sources:Amigo / QuickGO
Orthologs
	10146
	27041
	ENSG00000145907
	ENSMUSG00000018583
	Q13283
	P97855
	NM_005754; NM_198395
	NM_013716
	NP_005745; NP_938405
	NP_038744
	Wikidata
View/Edit Human	View/Edit Mouse

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.^[5]^[6]^[7]

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.^[8] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.^[7]

G3BP1 can initiate stress granule formation and labeled G3BP1 is commonly used as a marker for stress granules.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145907 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018583 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. doi:10.1128/MCB.16.6.2561. PMC 231246. PMID 8649363.
^ Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
^ ^a ^b "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
^ Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLOS ONE. 6 (12): e29024. Bibcode:2011PLoSO...629024A. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.
^ Mahboubi, Hicham; Stochaj, Ursula (2017-04-01). "Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863 (4): 884–895. doi:10.1016/j.bbadis.2016.12.022. ISSN 0925-4439. PMID 28095315.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145907 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018583 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8649363-5] Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. doi:10.1128/MCB.16.6.2561. PMC 231246. PMID 8649363.

[pmid9889278-6] Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.

[entrez-7] "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".

[8] Annibaldi, A; Dousse, A; Martin, S; Tazi, J; Widmann, C (2011). "Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1". PLOS ONE. 6 (12): e29024. Bibcode:2011PLoSO...629024A. doi:10.1371/journal.pone.0029024. PMC 3242762. PMID 22205990.

[9] Mahboubi, Hicham; Stochaj, Ursula (2017-04-01). "Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863 (4): 884–895. doi:10.1016/j.bbadis.2016.12.022. ISSN 0925-4439. PMID 28095315.

G3BP1 information

and 6 Related for: G3BP1 information

G3BP1

Stress granule

RNA recognition motif

HDAC6

RPTOR

USP10