LIN28 information

LIN28A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQF, 2LI8
Identifiers
Aliases	LIN28A, CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A, lin-28 homolog A, Lin28a, LIN28A (gene), Lin-28 homolog A
External IDs	OMIM: 611043 MGI: 1890546 HomoloGene: 32592 GeneCards: LIN28A
Gene location (Human)
Chr.	Chromosome 1 (human)
End	26,429,728 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	133,746,152 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; sperm; ; embryo; ; Achilles tendon; ; lower respiratory tract; ; lung; ; ovary; ; stomach; ; pancreas;
	Top expressed in
	primitive streak; ; otic placode; ; somite; ; yolk sac; ; secondary oocyte; ; abdominal wall; ; morula; ; bone marrow; ; ovary; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; metal ion binding; protein binding; RNA binding; nucleic acid binding; translation initiation factor binding; mRNA binding; G-quadruplex RNA binding; miRNA binding; sequence-specific mRNA binding; polysome binding;
Cellular component	cytoplasm; cytosol; nucleolus; nucleus; endoplasmic reticulum; rough endoplasmic reticulum; polysome; P-body; cytoplasmic stress granule; ribonucleoprotein complex;
Biological process	regulation of gene silencing by miRNA; germ cell development; miRNA catabolic process; regulation of transcription, DNA-templated; RNA 3'-end processing; somatic stem cell population maintenance; negative regulation of glial cell differentiation; positive regulation of translation; stem cell differentiation; positive regulation of cell proliferation involved in kidney development; stem cell population maintenance; pre-miRNA processing; positive regulation of neuron differentiation; miRNA metabolic process; gene silencing; negative regulation of translation; positive regulation of TOR signaling; positive regulation of protein kinase B signaling; cellular response to glucose stimulus; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of cytoplasmic translation;
	Sources:Amigo / QuickGO
Orthologs
	79727
	83557
	ENSG00000131914
	ENSMUSG00000050966
	Q9H9Z2
	Q8K3Y3
	NM_024674
	NM_145833
	NP_078950
	NP_665832
	Wikidata
View/Edit Human	View/Edit Mouse

Lin-28 homolog A is a protein that in humans is encoded by the LIN28 gene.^[5]^[6]

LIN28 encodes an RNA-binding protein^[7] that binds to and enhances the translation of the IGF-2 (insulin-like growth factor 2) mRNA.^[8] Lin28 binds to the let-7 pre-microRNA and blocks production of the mature let-7 microRNA in mouse embryonic stem cells.^[9]^[10] In pluripotent embryonal carcinoma cells, LIN28 is localized in the ribosomes, P-bodies and stress granules.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131914 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050966 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moss EG, Tang L (Jun 2003). "Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites". Developmental Biology. 258 (2): 432–42. doi:10.1016/S0012-1606(03)00126-X. PMID 12798299.
^ "Entrez Gene: LIN28 lin-28 homolog (C. elegans)".
^ Tsialikas J, Romer-Seibert J (Jul 2015). "LIN28: roles and regulation in development and beyond". Development. 142 (14): 2397–404. doi:10.1242/dev.117580. PMID 26199409.
^ Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss EG, Harel-Bellan A (May 2007). "Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency". Genes & Development. 21 (9): 1125–38. doi:10.1101/gad.415007. PMC 1855237. PMID 17473174.
^ Viswanathan SR, Daley GQ, Gregory RI (Apr 2008). "Selective blockade of microRNA processing by Lin28". Science. 320 (5872): 97–100. Bibcode:2008Sci...320...97V. doi:10.1126/science.1154040. PMC 3368499. PMID 18292307.
^ Ali PS, Ghoshdastider U, Hoffmann J, Brutschy B, Filipek S (Nov 2012). "Recognition of the let-7g miRNA precursor by human Lin28B". FEBS Letters. 586 (22): 3986–90. doi:10.1016/j.febslet.2012.09.034. PMID 23063642. S2CID 28899778.
^ Balzer E, Moss EG (2007). "Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules". RNA Biology. 4 (1): 16–25. doi:10.4161/rna.4.1.4364. PMID 17617744. S2CID 23979766.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131914 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050966 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12798299-5] Moss EG, Tang L (Jun 2003). "Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites". Developmental Biology. 258 (2): 432–42. doi:10.1016/S0012-1606(03)00126-X. PMID 12798299.

[entrez-6] "Entrez Gene: LIN28 lin-28 homolog (C. elegans)".

[Tsialikas2015-7] Tsialikas J, Romer-Seibert J (Jul 2015). "LIN28: roles and regulation in development and beyond". Development. 142 (14): 2397–404. doi:10.1242/dev.117580. PMID 26199409.

[pmid17473174-8] Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss EG, Harel-Bellan A (May 2007). "Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency". Genes & Development. 21 (9): 1125–38. doi:10.1101/gad.415007. PMC 1855237. PMID 17473174.

[pmid18292307-9] Viswanathan SR, Daley GQ, Gregory RI (Apr 2008). "Selective blockade of microRNA processing by Lin28". Science. 320 (5872): 97–100. Bibcode:2008Sci...320...97V. doi:10.1126/science.1154040. PMC 3368499. PMID 18292307.

[ali-10] Ali PS, Ghoshdastider U, Hoffmann J, Brutschy B, Filipek S (Nov 2012). "Recognition of the let-7g miRNA precursor by human Lin28B". FEBS Letters. 586 (22): 3986–90. doi:10.1016/j.febslet.2012.09.034. PMID 23063642. S2CID 28899778.

[pmid17617744-11] Balzer E, Moss EG (2007). "Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules". RNA Biology. 4 (1): 16–25. doi:10.4161/rna.4.1.4364. PMID 17617744. S2CID 23979766.

LIN28 information

and 14 Related for: LIN28 information

LIN28

Precocious puberty

Induced pluripotent stem cell

Healing

Regenerative medicine

Induced stem cells

Stem cell

MicroRNA

Dental pulp stem cell

Stress granule

L1TD1

ZCCHC6

Kevin Struhl

GLIS1