Class of membrane-less organelles within biological cells
See also: Cytoplasmic inclusions
In biochemistry, biomolecular condensates are a class of membrane-less organelles and organelle subdomains, which carry out specialized functions within the cell. Unlike many organelles, biomolecular condensate composition is not controlled by a bounding membrane. Instead, condensates can form and maintain organization through a range of different processes, the most well-known of which is phase separation of proteins, RNA and other biopolymers into either colloidal emulsions, gels, liquid crystals, solid crystals or aggregates within cells.[1]
^Garaizar, Adiran; Espinosa, Jorge R.; Joseph, Jerelle A.; Collepardo-Guevara, Rosana (2022-03-15). "Kinetic interplay between droplet maturation and coalescence modulates shape of aged protein condensates". Scientific Reports. 12 (1): 4390. Bibcode:2022NatSR..12.4390G. doi:10.1038/s41598-022-08130-2. ISSN 2045-2322. PMC 8924231. PMID 35293386.
and 22 Related for: Biomolecular condensate information
In biochemistry, biomolecularcondensates are a class of membrane-less organelles and organelle subdomains, which carry out specialized functions within...
near the speed of light Top quark condensate, an alternative theory to the Standard Model Biomolecularcondensate This disambiguation page lists articles...
biomolecularcondensates—similar in importance to compartmentalisation via lipid bilayer membranes, a type of liquid crystal. The term biomolecular condensate...
mammary cells in the form of colloidal casein micelles, a type of biomolecularcondensate. As a food source, casein supplies amino acids, carbohydrates,...
Examples of emulsions include vinaigrettes, homogenized milk, liquid biomolecularcondensates, and some cutting fluids for metal working. Two liquids can form...
fixation such as RuBisCO. Non-membrane bound organelles can form as biomolecularcondensates, which arise by clustering, oligomerisation, or polymerisation...
formation or an exotic Fulde-Ferrell-Larkin-Ovchinnikov phase. Biomolecularcondensate Colloid Phase diagram Phase rule UNIQUAC Nic M, Jirat J, Kosata...
effective concentrations. Crowding can promote formation of a biomolecularcondensate by colloidal phase separation. This crowding effect can make molecules...
(oligomerisation or polymerisation) and/or colloidal phase separation to form biomolecularcondensates that increase the local concentration and signalling activity of...
disordered proteins Folding funnel Fuzzy complex Hydrophobic collapse Biomolecularcondensate Kim, P. S.; Baldwin, R. L. (1990). "Intermediates in the folding...
principle role in the cell as a scaffold to generate membrane-less biomolecularcondensates through liquid-liquid phase separation. Mutations in the phase-separating...
In cellular biology, stress granules are biomolecularcondensates in the cytosol composed of proteins and RNAs that assemble into 0.1–2 μm membraneless...
sphere-, rod-, or sheet-like species. Colloids, liquid crystals, biomolecularcondensates, micelles, liposomes and biological membranes are examples of supramolecular...
transcription occurs in the cell nucleus, and are an example of a biomolecularcondensate. They were first discovered in 1993 and have been found to have...
type of polymer. Membraneless organelles (MLOs), also known as biomolecularcondensates, are a form of cell compartmentalization. Unlike classic membrane-bound...
network connectivity regulates the stability and composition of biomolecularcondensates with many components. Proceedings of the National Academy of Sciences...
complex and contain multiple organelles, the cytoskeleton and biomolecularcondensates.the word protoplasm is mainly divided in to two parts cytoplasm...
aggregates. For biopolymers, association leads to formation of biomolecularcondensates, micelles and other examples of molecular self-assembly. Morawetz...
Molecular Biology Laboratory in Heidelberg, Germany, who utilizes biomolecularcondensates and advanced cellular cryo-electron tomography to enhance the comprehension...
Specifically, cell differentiation in animals is highly dependent on biomolecularcondensates of regulatory proteins and enhancer DNA sequences. Cellular differentiation...