'Staphylococcus aureus delta toxin is a toxin produced by Staphylococcus aureus.[1] It has a wide spectrum of cytolytic activity.[2]
It is among other toxins produced by S. aureus and is part of the phenol-soluble modulin peptide family.[3] Its alpha-helical, amphipathic structure gives it detergent-like properties, allowing it to disrupt and attach to the cytoplasmic membrane of a cell non-specifically, without a receptor, and integrate into the membrane.[4][5] Delta toxin degrades the membrane on contact and forms short-lived pores, causing cell lysis and subsequent cell death.[5]
^Nolte FS, Kapral FA (March 1981). "Immunogenicity of Staphylococcus aureus delta-toxin". Infection and Immunity. 31 (3): 1251–60. PMC 351449. PMID 7014461.
^Murray PR, Rosenthal KS, Pfaller MA (2009) [1990]. Medical Microbiology (6th ed.). Philadelphia: Mosby. p. 213. ISBN 978-0-323-05470-6.
^Cheung GY, Yeh AJ, Kretschmer D, Duong AC, Tuffuor K, Fu CL, Joo HS, Diep BA, Li M, Nakamura Y, Nunez G, Peschel A, Otto M (December 2015). "Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S". Scientific Reports. 5 (1): 18023. doi:10.1038/srep18023. PMC 4674873. PMID 26658455.
^Bloes DA, Haasbach E, Hartmayer C, Hertlein T, Klingel K, Kretschmer D, Planz O, Peschel A (December 2017). "Phenol-Soluble Modulin Peptides Contribute to Influenza A Virus-Associated Staphylococcus aureus Pneumonia". Infection and Immunity. 85 (12): e00620–17. doi:10.1128/IAI.00620-17. PMC 5695099. PMID 28893917.
^ abOtto M (February 2014). "Staphylococcus aureus toxins". Current Opinion in Microbiology. 17: 32–7. doi:10.1016/j.mib.2013.11.004. PMC 3942668. PMID 24581690.
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