Soluble transferrin receptor conventionally refers to the cleaved extracellular portion of transferrin receptor 1 that is released into serum. This receptor is a protein dimer of two identical subunits, linked together by two pairs of disulfide bonds.
Its molecular mass 190,000 Dalton.[1]
Blood testing of the soluble transferrin receptor (sTfR) is used as a measure of functional iron status and the investigation of iron deficiency anemia. Ferritin, a routine investigation for anemia, is an acute-phase reactant, and may be elevated in states of inflammation, thereby falsely indicating that iron stores are adequate.[2] Because sTfR is insensitive to inflammation, it can detect anemia in patients with preexisting inflammatory states, and is particularly useful in distinguishing between the anemia of chronic disease and anemias caused by lack of iron intake.[3]
To date, the conventionally identified soluble transferrin receptor has not been itself implicated in intracellular delivery of transferrin and associated iron stores.
A soluble receptor for any ligand could also refer to a molecule present is solution (for example a secretory protein) which would bind with the target ligand and then effect cellular delivery. In this context the multifunctional glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported as a soluble receptor for transferrin. It has been demonstrated to deliver more transferrin as compared to the receptors anchored on the cells surface in numerous cell types.[4]
^Cook, J. D.; Skikne, B. S.; Baynes, R. D. (1 February 1993). "Serum Transferrin Receptor". Annual Review of Medicine. 44 (1): 63–74. doi:10.1146/annurev.me.44.020193.000431. PMID 8476268.
^Skikne, Barry S. (1 November 2008). "Serum transferrin receptor". American Journal of Hematology. 83 (11): 872–875. doi:10.1002/ajh.21279. PMID 18821709. S2CID 19440553.
^Ferguson, BJ; Skikne, BS; Simpson, KM; Baynes, RD; Cook, JD (April 1992). "Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia". The Journal of Laboratory and Clinical Medicine. 119 (4): 385–90. PMID 1583389.
^Secreted glyceraldehyde-3-phosphate dehydrogenase is a multifunctional autocrine transferrin receptor for cellular iron acquisition
Navdeep Sheokand, Santosh Kumar, Himanshu Malhotra, Vikas Tillu, Chaaya Iyengar Raje, and Manoj Raje Biochimica et Biophysica Acta (BBA) - General Subjects; 2013, 1830: 3816–3827.
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transferrin that would potentially attach to transferrinreceptors on cancer cell surfaces. There is very high selectivity for transferrinreceptors because...
apoptotic death of Fas receptor-bearing cells, e.g. cytotoxic T cells. - soluble FasL: increasing the effectivity of the system - soluble Fas: FasL blockage...
iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency...
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C) induces apoptosis in melanoma cells via the down-regulation of transferrinreceptor dependent iron uptake". J. Cell. Physiol. 204 (1): 192–7. doi:10...
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Ferritin Fibrin Haptoglobin Hemopexin Orosomucoid Negative Serum albumin Transferrin Lymphatic system Primary lymphoid organs Thymus - Site of T cell maturation...
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(RGMc) or hemochromatosis type 2 protein (HFE2), is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition...
genes into tumours, using an antibody fragment against the human transferrinreceptor. Tissue-specific gene delivery using immunoliposomes has been achieved...
transporters such as glucose and amino acid carriers, receptor-mediated transcytosis for insulin or transferrin. Nilsson LG, Markowitsch HJ (1999). Cognitive...
bound to and transported by albumin (60%, low-affinity) and transferrin (10%). Because transferrin also transports iron, excessive iron reduces zinc absorption...
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