Protein-coding gene in the species Homo sapiens
ACO1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B3X, 2B3Y
Identifiers Aliases ACO1 , ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1, aconitase 1External IDs OMIM: 100880; MGI: 87879; HomoloGene: 1657; GeneCards: ACO1; OMA:ACO1 - orthologs Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.1 Start 32,384,603 bp[1] End 32,454,769 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 A5|4 20.24 cM Start 40,143,081 bp[2] End 40,198,338 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver stromal cell of endometrium right adrenal gland right adrenal cortex adipose tissue left adrenal gland kidney tubule subcutaneous adipose tissue duodenum jejunal mucosa
Top expressed in tunica adventitia of aorta external carotid artery internal carotid artery migratory enteric neural crest cell dermis efferent ductule carotid body tunica media of zone of aorta submandibular gland proximal tubule
More reference expression data
BioGPS
Gene ontology Molecular function
iron-sulfur cluster binding
metal ion binding
protein binding
lyase activity
RNA binding
aconitate hydratase activity
iron-responsive element binding
3 iron, 4 sulfur cluster binding
4 iron, 4 sulfur cluster binding Cellular component
Golgi apparatus
endoplasmic reticulum
mitochondrion
extracellular exosome
cytoplasm
cytosol Biological process
response to iron(II) ion
tricarboxylic acid cycle
post-embryonic development
regulation of gene expression
intestinal absorption
metabolism
regulation of translation
citrate metabolic process
cellular iron ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez Ensembl UniProt RefSeq (mRNA) NM_001278352
RefSeq (protein) NP_001265281
Location (UCSC) Chr 9: 32.38 – 32.45 Mb Chr 4: 40.14 – 40.2 Mb PubMed search [3] [4]
Wikidata View/Edit Human View/Edit Mouse
Aconitase 1, soluble is a protein that in humans is encoded by the ACO1 gene.[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000122729 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Entrez Gene: Aconitase 1, soluble".
Last Update: 2022-07-12T09:50:00Z
Aconitase 1, soluble is a protein that in humans is encoded by the ACO1 gene. The protein encoded by this gene is a bifunctional, cytosolic protein that...
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Last Update: 2024-03-06T05:10:25Z
aconitase 1, soluble Identifiers Symbol ACO1 Alt. symbols IREB1 NCBI gene 48 HGNC 117 OMIM 100880 RefSeq NM_002197 UniProt P21399 Other data EC number...
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Last Update: 2024-05-14T16:34:22Z
Wang-jin; Chen, Jian-ye (October 2020). "MaXB3 Modulates MaNAC2, MaACS1, and MaACO1 Stability to Repress Ethylene Biosynthesis during Banana Fruit Ripening"...
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Last Update: 2024-06-11T02:04:11Z
the protein into the cytoplasm. Within the 3’ UTR, the RBMY1A1, RBMX, and ACO1 proteins were some of the top scoring RBPs. The RBMY1A1 is a protein known...
Word Count : 3870
Last Update: 2024-04-30T08:44:55Z
exons. The 5' UTR is bound by the RNA binding proteins RBMX1, FUS, SFRS1, ACO1 , and NONO. The 3' UTR is bound by EIF4B, A2BP1, and ZFP36. A single non-coding...
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Last Update: 2024-01-19T13:10:54Z
to Nbp35 homologue's of NUBP1. NUBP2 has been shown to interact with... ACO1 Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatory protein...
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Last Update: 2024-03-31T08:25:02Z
for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 . The function of GLRX5 is highly conserved evolutionarily. Mutations in the...
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