Crystallographic structure of mitochondrial ferritin.[2]
Identifiers
Symbol
FTMT
NCBI gene
94033
HGNC
17345
OMIM
608847
RefSeq
NM_177478
UniProt
Q8N4E7
Other data
Locus
Chr. 5 q23.1
Search for
Structures
Swiss-model
Domains
InterPro
Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including archaea, bacteria, algae, higher plants, and animals. It is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency and iron overload.[3]
Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia.[4] Aggregated ferritin transforms into a toxic form of iron called hemosiderin.[5]
Ferritin is a globular protein complex consisting of 24 protein subunits forming a hollow nanocage with multiple metal–protein interactions.[6] Ferritin that is not combined with iron is called apoferritin.[citation needed]
^PDB: 1lb3; Granier T, Langlois d'Estaintot B, Gallois B, Chevalier JM, Précigoux G, Santambrogio P, Arosio P (January 2003). "Structural description of the active sites of mouse L-chain ferritin at 1.2 A resolution". Journal of Biological Inorganic Chemistry. 8 (1–2): 105–11. doi:10.1007/s00775-002-0389-4. PMID 12459904. S2CID 20756710.
^PDB: 1r03; Langlois d'Estaintot B, Santambrogio P, Granier T, Gallois B, Chevalier JM, Précigoux G, Levi S, Arosio P (July 2004). "Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala". Journal of Molecular Biology. 340 (2): 277–93. doi:10.1016/j.jmb.2004.04.036. PMID 15201052.
^Casiday R, Frey R. "Iron Use and Storage in the Body: Ferritin and Molecular Representations". Department of Chemistry, Washington University in St. Louis.
^MacKenzie EL, Iwasaki K, Tsuji Y (June 2008). "Intracellular iron transport and storage: from molecular mechanisms to health implications". Antioxidants & Redox Signaling. 10 (6): 997–1030. doi:10.1089/ars.2007.1893. PMC 2932529. PMID 18327971.
Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms...
Ferritin light chain is a protein that in humans is encoded by the FTL gene. Ferritin is the major protein responsible for storing intracellular iron...
associated with ferritin is a quantum biological process, and ferritin is a quantum biological agent. Electron tunneling through ferritin between electrodes...
haemosiderin is an iron-storage complex that is composed of partially digested ferritin and lysosomes. The breakdown of heme gives rise to biliverdin and iron...
arthritis in those with hemochromatosis include elevated iron levels (ferritin greater than 1000 or transferrin saturation greater than 50%) for an extended...
Mitochondrial ferritin is a ferroxidase enzyme that in humans is encoded by the FTMT gene. It is classified as a metal-binding protein which is located...
protein, erythrocyte sedimentation rate, and ferritin level are markedly elevated. In children, a ferritin above 10000 is very sensitive and specific for...
saturation or elevated serum ferritin. Arthropathy with stiff joints, diabetes, or fatigue, may be the presenting complaint. Serum ferritin and fasting transferrin...
early diagnosis of hereditary hemochromatosis, especially while serum ferritin still remains low. The retained iron in hereditary hemochromatosis is primarily...
includes ferritin and hemosiderin, rather than iron in the ferrous state. Perls's method is used to indicate "non-heme" iron in tissues such as ferritin and...
properties of the ferritin. The ferritin is composed of 24 subunits of protein complex and a small iron oxide core. The core of the ferritin is in the form...
Fe2O3 + 3 C → 4 Fe + 3 CO2 Iron is stored in many organisms in the form of ferritin, which is a ferrous oxide encased in a solubilizing protein sheath. Species...
type of inclusion body composed of ferritin aggregates, or mitochondria or phagosomes containing aggregated ferritin. They appear as dense, blue-purple...
Ferritin heavy chain 1 pseudogene 3 is a protein that, in humans, is encoded by the FTH1P3 gene. "Human PubMed Reference:". National Center for Biotechnology...
to the presence of iron in at least two different forms: hemoglobin and ferritin. The structure is located in the tegmentum of the midbrain next to the...
contained in ferritin complexes that are present in all cells, but most common in bone marrow, liver, and spleen. The liver stores of ferritin are the primary...
individual clinical situation. Serum ferritin can be elevated in inflammatory conditions; so a normal serum ferritin may not always exclude iron deficiency...
the bone marrow, transferrin is reduced from Fe3+ and Fe2+ and stored as ferritin to be incorporated into hemoglobin. The most commonly known and studied...
complete blood count hemoglobin serum iron total iron binding capacity serum ferritin bone marrow examination (rarely) Note: Iron therapy must be suspended 48...
early diagnosis of Hereditary hemochromatosis, especially while serum ferritin still remains low. The retained iron in Hereditary hemochromatosis is primarily...
the presence of disordered arrays of ferritin in SNc tissue. The hypothesis also predicted that disordered ferritin arrays like those found in SNc tissue...
mutations in the gene encoding the light chain subunit of the ferritin protein. Wild type ferritin functions as a buffer for iron, sequestering it and controlling...
Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes...
autoantibodies (ANA, anti-smooth muscle, antimitochondria, anti-LKM) Ferritin and transferrin saturation: markers of iron overload as in hemochromatosis...
diagnostically established and verified via laboratory tests (e.g., low ferritin concentration, low transferrin saturation). The drug has been on the market...
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