positive regulation of extracellular matrix disassembly
iron ion homeostasis
negative regulation of substrate adhesion-dependent cell spreading
regulation of cell population proliferation
positive regulation of plasminogen activation
ion transport
regulation of cell growth
C-terminal protein lipidation
post-translational protein modification
transport
iron ion transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
4241
30060
Ensembl
ENSG00000163975
ENSMUSG00000022780
UniProt
P08582
Q9R0R1
RefSeq (mRNA)
NM_005929 NM_033316
NM_013900
RefSeq (protein)
NP_005920 NP_201573
NP_038928
Location (UCSC)
Chr 3: 196.98 – 197.03 Mb
Chr 16: 31.7 – 31.72 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[5] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.
^ abcGRCh38: Ensembl release 89: ENSG00000163975 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022780 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5".
Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228)...
transferrin; egg white ovotransferrin (conalbumin); and membrane-associated melanotransferrin. Beta-2 transferrin Transferrin receptor Total iron-binding capacity...
(epithelial membrane antigen), to identify various tumours etc. CD228 Melanotransferrin (MFI2). This protein is a cell-surface glycoprotein found on melanoma...
types. The reason for this postulation is based on the expression of melanotransferrin (melanoma-specific peptide that may play role in iron metabolism)...