Vacuole to which materials ingested by endocytosis are delivered
"Endosoma" redirects here. For Endosomaphilia, see Vorarephilia.
Electron micrograph of endosomes in human HeLa cells. Early endosomes (E - labeled for EGFR, 5 minutes after internalisation, and transferrin), late endosomes/MVBs (M) and lysosomes (L) are visible. Bar, 500 nm.
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus.
Endosomes can be classified as early, sorting, or late depending on their stage post internalization.[1] Endosomes represent a major sorting compartment of the endomembrane system in cells.[2]
^Stoorvogel W, Strous GJ, Geuze HJ, Oorschot V, Schwartz AL (May 1991). "Late endosomes derive from early endosomes by maturation". Cell. 65 (3): 417–27. doi:10.1016/0092-8674(91)90459-C. PMID 1850321. S2CID 31539542.
^Mellman I (1996). "Endocytosis and molecular sorting". Annual Review of Cell and Developmental Biology. 12: 575–625. doi:10.1146/annurev.cellbio.12.1.575. PMID 8970738.
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of the endocytic membrane transport pathway originating...
slow manner. The trophozoite has a single nucleus, prominent for nuclear endosome and many cytoplasmic vacuoles. The ectoplasm and the granular endoplasm...
back to the surface (as in early endosomes and recycling endosomes), or sort them to degradation (as in late endosomes and lysosomes). The principal components...
encodes for the 1400 amino acid protein, Early Endosome Antigen 1. EEA1 localizes exclusively to early endosomes and has an important role in endosomal trafficking...
vesicles called endosomes. There are three compartments involved in this antigen presentation pathway: early endosomes, late endosomes or endolysosomes...
the stack, but can also be separate from it. The TGN may act as an early endosome in yeast and plants. There are structural and organizational differences...
entry into the host cell within an endosome. Once the virus has successfully gained entry into the host cell, the endosome acidifies, which alters virus topology...
sortilin functions in protein transport between the Golgi apparatus, endosome, lysosome, and plasma membrane, leading to its involvement in multiple...
the cell to internalize the toxin within an endosome via receptor-mediated endocytosis. Inside the endosome, DT is split by a trypsin-like protease into...
transporting select cargo proteins between vesicular structures (e.g., endosomes, lysosomes, vacuoles) and the Golgi apparatus. Mutations in the VPS35...
component membrane cell surface integral component of membrane recycling endosome intracellular anatomical structure integral component of plasma membrane...
during the receptor's repeated trips to the highly acidic interior of the endosome. The exact mechanism of interaction between the class A repeats and ligand...
a process in which ubiquitin-tagged proteins enter organelles called endosomes via the formation of vesicles. This process is essential for cells to...
virus into the cell by way of an endosome. The virus then uses the acidic environment, which is necessary, of that endosome and binds to its membrane simultaneously...
the endosome. Once formed, the endosome combines with a structure known as a multivesicular body (MVB). The MVB containing segregated endosomes ultimately...
Alzheimer’s patients. Retromer regulates protein trafficking from the early endosome either back to the trans-Golgi (retrograde) or back to the plasma membrane...
the virus is internalized into the cell by an endosome that contains the virion inside it. The endosome is acidified by cellular vATPase to have lower...
localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to late endosomes. It drives the maturation...
initial stages of endocytosis, through its interaction with the early endosome. In addition, Rab-4B is thought to be important in the insulin pathway...
AA, Voeltz GK (6 February 2013). "Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature". Molecular Biology of the Cell. 24...
regulation of autophagy response to mitochondrial depolarisation early endosome to late endosome transport negative regulation of autophagy positive regulation...
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