STAT1 information

STAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WWT, 1BF5, 1YVL, 2KA6
Identifiers
Aliases	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
External IDs	OMIM: 600555 MGI: 103063 HomoloGene: 21428 GeneCards: STAT1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	191,020,960 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	52,201,024 bp
RNA expression pattern
	Top expressed in
	appendix; ; monocyte; ; endothelial cell; ; lymph node; ; glomerulus; ; metanephric glomerulus; ; germinal epithelium; ; trigeminal ganglion; ; gallbladder; ; palpebral conjunctiva;
	Top expressed in
	thymus; ; spleen; ; submandibular gland; ; blood; ; subcutaneous adipose tissue; ; mucous cell of stomach; ; brown adipose tissue; ; white adipose tissue; ; right lung; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein homodimerization activity; DNA-binding transcription factor activity; RNA polymerase II general transcription initiation factor activity; signal transducer activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; identical protein binding; enzyme binding; tumor necrosis factor receptor binding; double-stranded DNA binding; RNA polymerase II core promoter sequence-specific DNA binding; cadherin binding; histone acetyltransferase binding; histone binding; ubiquitin-like protein ligase binding; promoter-specific chromatin binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; CCR5 chemokine receptor binding; protein phosphatase 2A binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleoplasm; nucleolus; perinuclear region of cytoplasm; nucleus; cytosol; axon; dendrite; protein-containing complex;
Biological process	regulation of apoptotic process; metanephric mesenchymal cell proliferation involved in metanephros development; regulation of transcription, DNA-templated; cellular response to interferon-beta; regulation of transcription by RNA polymerase II; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; metanephric mesenchymal cell differentiation; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription by RNA polymerase II; renal tubule development; response to interferon-beta; negative regulation of I-kappaB kinase/NF-kappaB signaling; transcription, DNA-templated; negative regulation of endothelial cell proliferation; regulation of type I interferon-mediated signaling pathway; regulation of interferon-gamma-mediated signaling pathway; positive regulation of mesenchymal cell proliferation; negative regulation of metanephric nephron tubule epithelial cell differentiation; negative regulation of angiogenesis; negative regulation by virus of viral protein levels in host cell; viral process; endothelial cell migration; positive regulation of transcription by RNA polymerase II; signal transduction; macrophage derived foam cell differentiation; positive regulation of erythrocyte differentiation; type I interferon signaling pathway; cellular response to interferon-gamma; positive regulation of defense response to virus by host; positive regulation of interferon-alpha production; positive regulation of transcription, DNA-templated; defense response to virus; interferon-gamma-mediated signaling pathway; receptor signaling pathway via JAK-STAT; response to nutrient; blood circulation; positive regulation of cell population proliferation; response to mechanical stimulus; response to organic cyclic compound; cellular response to insulin stimulus; response to cytokine; response to hydrogen peroxide; response to peptide hormone; positive regulation of smooth muscle cell proliferation; response to cAMP; positive regulation of nitric-oxide synthase biosynthetic process; cellular response to cytokine stimulus; cellular response to organic cyclic compound; positive regulation of transcription of Notch receptor target; cytokine-mediated signaling pathway; interleukin-21-mediated signaling pathway; interleukin-6-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; interleukin-9-mediated signaling pathway; defense response; regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	6772
	20846
	ENSG00000115415
	ENSMUSG00000026104
	P42224
	P42225
	NM_007315; NM_139266
	NM_001205313; NM_001205314; NM_009283; NM_001357627
	NP_009330; NP_644671
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115415 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026104 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Subedi P, Huber K, Sterr C, Dietz A, Strasser L, Kaestle F, Hauck SM, Duchrow L, Aldrian C, Monroy Ordonez EB, Luka B, Thomsen AR, Henke M, Gomolka M, Rößler U, Azimzadeh O, Moertl S, Hornhardt S (2023). "Towards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics". Frontiers in Oncology. 13. doi:10.3389/fonc.2023.1180642. PMC 10298177. PMID 37384298.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115415 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026104 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Subedi P, Huber K, Sterr C, Dietz A, Strasser L, Kaestle F, Hauck SM, Duchrow L, Aldrian C, Monroy Ordonez EB, Luka B, Thomsen AR, Henke M, Gomolka M, Rößler U, Azimzadeh O, Moertl S, Hornhardt S (2023). "Towards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics". Frontiers in Oncology. 13. doi:10.3389/fonc.2023.1180642. PMC 10298177. PMID 37384298.

STAT1 information

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