Crystallographic structure of the SH2 domain. The structure consists of a large beta sheet (green) flanked by two alpha-helices (orange and blue).[1]
Identifiers
Symbol
SH2
Pfam
PF00017
InterPro
IPR000980
SMART
SH2
PROSITE
PDOC50001
SCOP2
1sha / SCOPe / SUPFAM
CDD
cd00173
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein[2] and in many other intracellular signal-transducing proteins.[3] SH2 domains bind to phosphorylated tyrosine residues on other proteins, modifying the function or activity of the SH2-containing protein. The SH2 domain may be considered the prototypical modular protein-protein interaction domain, allowing the transmission of signals controlling a variety of cellular functions.[4] SH2 domains are especially common in adaptor proteins that aid in the signal transduction of receptor tyrosine kinase pathways.[5]
^PDB: 1lkk; Tong L, Warren TC, King J, Betageri R, Rose J, Jakes S (March 1996). "Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution". Journal of Molecular Biology. 256 (3): 601–10. doi:10.1006/jmbi.1996.0112. PMID 8604142.
^Sadowski I, Stone JC, Pawson T (December 1986). "A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps". Molecular and Cellular Biology. 6 (12): 4396–408. doi:10.1128/mcb.6.12.4396. PMC 367222. PMID 3025655.
^Russell RB, Breed J, Barton GJ (June 1992). "Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains". FEBS Letters. 304 (1): 15–20. doi:10.1016/0014-5793(92)80579-6. PMID 1377638. S2CID 7046771.
^Pawson T, Gish GD, Nash P (December 2001). "SH2 domains, interaction modules and cellular wiring". Trends in Cell Biology. 11 (12): 504–511. doi:10.1016/s0962-8924(01)02154-7. PMID 11719057.
^Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G (May 2013). "Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected". Molecular & Cellular Proteomics. 12 (5): 1204–13. doi:10.1074/mcp.M112.025858. PMC 3650332. PMID 23358503.
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing...
contain six conserved domains: a N-terminal myristoylated segment, a SH2domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail...
one SH2domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2domain binds...
via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2domains". The Journal of Biological...
SH2 may stand for: SH2 (classification), a Paralympic shooting classification SH2domain (Src Homology 2), a protein domain within the Src oncoprotein...
PLCγ by its SH2domains. Figure 1 on the extreme right shows the PLCγ-FGFR1 kinase complex with the c-SH2domain colored in red, n-SH2domain colored in...
possesses a domain structure that consists of two tandem SH2domains in its N-terminus followed by a protein tyrosine phosphatase (PTP) domain. In the inactive...
memory T cells. These differences are due to differential regulation by SH2domain–containing phosphatase-1 (Shp-1) and C-terminal Src kinase. Lck is responsible...
Adaptor proteins usually contain several domains within their structure (e.g., Src homology 2 (SH2) and SH3 domains) that allow specific interactions with...
membrane trafficking. Src homology 2 domain (SH2): SH2domains are often found in signal transduction proteins. SH2domains confer binding to phosphorylated...
Hematopoietic SH2Domain Containing (HSH2D) protein is a protein encoded by the hematopoietic SH2domain containing (HSH2D) gene. HSH2D is located on chromosome...
(SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and...
C-terminal C2 domain. Specific to the PLCG isozymes is a large separation between the X and Y domains consisting of a split PH domain, tandem SH2domains, and...
RTKs are recognized by a phosphodependent-binding domain, the SH2domain. The recruitment of SH2domain proteins to autophosphorylated RTKs at the plasma...
docking site to which a number of signaling proteins bind, including the SH2-domain-containing leukocyte protein of 76 kDa (SLP-76). SLP-76 is also phosphorylated...
"Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2domain". Proc Natl Acad Sci U S A. 93 (12): 5991–5. Bibcode:1996PNAS...93.5991J...
C-terminal GAP domain Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2domains The protein encoded...
cytoplasmic signaling protein which contains an SH2domain flanked by two SH3 domains. The SH2domain interacts with ligand-activated receptors for stem...
In molecular biology, the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7/|Grb10/Grb14...
mammalian cells. SCOP classifies the 3D structure as belonging to the SH2domain family. The gene SHC1 is located on chromosome 1 and encodes 3 main protein...
SH2domain-containing protein 2A is a protein that in humans is encoded by the SH2D2A gene. SH2D2A has been shown to interact with MAP3K2. GRCh38: Ensembl...
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