PIAS1 information

PIAS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V66
Identifiers
Aliases	PIAS1, DDXBP1, GBP, GU/RH-II, ZMIZ3, protein inhibitor of activated STAT 1
External IDs	OMIM: 603566 MGI: 1913125 HomoloGene: 22953 GeneCards: PIAS1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	68,198,603 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	62,895,206 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; seminal vesicula; ; nipple; ; caput epididymis; ; bone marrow cells; ; cardia; ; trabecular bone; ; Achilles tendon; ; blood; ; pylorus;
	Top expressed in
	spermatid; ; secondary oocyte; ; seminiferous tubule; ; pineal gland; ; spermatocyte; ; olfactory tubercle; ; right ventricle; ; paraventricular nucleus of hypothalamus; ; carotid body; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; transcription corepressor activity; transcription coactivator activity; zinc ion binding; transcription factor binding; metal ion binding; SUMO ligase activity; protein binding; androgen receptor binding; enzyme binding; ubiquitin protein ligase binding; protein domain specific binding; SUMO transferase activity; transferase activity; protein C-terminus binding;
Cellular component	PML body; nuclear speck; nucleoplasm; nucleus;
Biological process	androgen receptor signaling pathway; receptor signaling pathway via JAK-STAT; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; protein sumoylation; transcription, DNA-templated; regulation of interferon-gamma-mediated signaling pathway; regulation of cell population proliferation; fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; visual learning; negative regulation of apoptotic process; positive regulation of smooth muscle cell differentiation; spermatogenesis; positive regulation of protein sumoylation; protein-DNA complex assembly; positive regulation of transcription, DNA-templated; G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	8554
	56469
	ENSG00000033800
	ENSMUSG00000032405
	O75925
	O88907
	NM_016166; NM_001320687
	NM_019663
	NP_001307616; NP_057250
	NP_062637
	Wikidata
View/Edit Human	View/Edit Mouse

E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000033800 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032405 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–10631. Bibcode:1998PNAS...9510626L. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.
^ Valdez BC, Henning D, Perlaky L, Busch RK, Busch H (July 1997). "Cloning and characterization of Gu/RH-II binding protein". Biochem Biophys Res Commun. 234 (2): 335–340. doi:10.1006/bbrc.1997.6642. PMID 9177271.
^ "Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000033800 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032405 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9724754-5] Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (September 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–10631. Bibcode:1998PNAS...9510626L. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.

[pmid9177271-6] Valdez BC, Henning D, Perlaky L, Busch RK, Busch H (July 1997). "Cloning and characterization of Gu/RH-II binding protein". Biochem Biophys Res Commun. 234 (2): 335–340. doi:10.1006/bbrc.1997.6642. PMID 9177271.

[entrez-7] "Entrez Gene: PIAS1 protein inhibitor of activated STAT, 1".

PIAS1 information

and 23 Related for: PIAS1 information

PIAS1

Signal peptide

Ubiquitin ligase

Protein inhibitor of activated STAT

Heat shock protein

Ubiquitin

Chaperonin

P53

Protein targeting

Hsp70

Mdm2

Binding immunoglobulin protein

SMN1

Clusterin

GroEL

Protein folding

SUMO protein

Succinylation

STAT1

Hsp90

ATG8

Sp3 transcription factor

Survival of motor neuron